Design, synthesis and structure-activity relationships of novel macrolones: Hybrids of 2-fluoro 9-oxime ketolides and carbamoyl quinolones with highly improved …

CX Ma, W Lv, YX Li, BZ Fan, X Han, FS Kong… - European Journal of …, 2019 - Elsevier
Constitutively erythromycin-resistant apathogens are more difficult to address than inducibly
resistant and efflux-resistant strains. Three series of the 4th generation 2-fluoro 9-oxime …

A novel class of fast‐acting antimalarial agents: Substituted 15‐membered azalides

M Peric, D Pešić, S Alihodžić, A Fajdetić… - British journal of …, 2021 - Wiley Online Library
Background and Purpose Efficacy of current antimalarial treatments is declining as a result
of increasing antimalarial drug resistance, so new and potent antimalarial drugs are urgently …

[HTML][HTML] Novel potential treatable traits in asthma: Where is the research taking us?

TF Carr, MC Peters - Journal of Allergy and Clinical Immunology: Global, 2022 - Elsevier
Asthma is a complex, heterogeneous disease in which the underlying mechanisms are not
fully understood. Patients are often grouped into phenotypes (based on clinical, biologic …

Anticancer activities, structure–activity relationship, and mechanism of action of 12‐, 14‐, and 16‐membered macrolactones

R Wang - Archiv der Pharmazie, 2021 - Wiley Online Library
Cancer remains one of the major causes of death worldwide despite the encouraging
breakthroughs in the discovery of novel chemotherapeutic agents in recent years. The …

4 Hybrids of macrolides and nucleobases or nucleosides: synthetic strategies and biological results

F Sodano, MG Rimoli - degruyter.com
In the literature, suitable reaction conditions have been described to link nucleobases and
nucleosides to erythromycin A derivatives without causing undesired reactions in the …

[PDF][PDF] Indomethacin hybrids as novel cytotoxic compounds

F Yazdi, M Abbasi, H Sadeghi-Aliabadi - Iranian Journal of …, 2017 - academia.edu
Cancer is still one of the most invasive health problems around the world although many
researches have been done in this field. Different kinds of drugs are developed and used to …

[引用][C] Hybrid Molecules with Potential Activity Against Methicillin-resistance Staphylococcus aureus Part I

Z Xu - Current Topics in Medicinal Chemistry, 2021 - ingentaconnect.com
Staphylococcus aureus (S. aureus), one of the most common pathogens of community and
nosocomial infection, can cause various infections ranging from superficial to life …