Bile acids (BAs) can regulate their own metabolism and transport as well as other key
aspects of metabolic homeostasis via dedicated (nuclear and G protein-coupled) receptors …

The history of brain drug delivery is reviewed beginning with the first demonstration, in 1914,
that a drug for syphilis, salvarsan, did not enter the brain, due to the presence of a blood …

Metabolism has historically been studied at the levels of whole cells, whole tissues and
whole organisms. As a result, our understanding of how compartmentalization—the spatial …

Cancer cells are metabolically vigorous and are superior in the uptake of nutrients and in the
release of the tumor microenvironment (TME)-specific metabolites. They create an acidic …

Global warming is increasingly exacerbating biodiversity loss. Populations locally adapted
to spatially heterogeneous environments may respond differentially to climate change, but …

Within the growing field of amino acid metabolism, tryptophan (Trp) catabolism is an area of
increasing interest. Trp is essential for protein synthesis, and its metabolism gives rise to …

The solute carrier (SLC) superfamily represents the biggest family of transporters with
important roles in health and disease. Despite being attractive and druggable targets, the …

Background Many molecular alterations are shared by embryonic liver development and
hepatocellular carcinoma (HCC). Identifying the common molecular events would provide a …

Bile acids (BAs) are important steroidal molecules with a rapidly growing span of
applications across a variety of fields such as supramolecular chemistry, pharmacy, and …

Ageing is a complex process with common and distinct features across tissues. Unveiling
the underlying processes driving ageing in individual tissues is indispensable to decipher …