Many organic cations (OCs) may be transported through membranes by a genetically still
uncharacterized proton-organic cation (H+ OC) antiporter. Here, we characterized an …

Introduction The prodrug approach has been thought to be a simple solution to improve
brain drug delivery for decades. Nevertheless, it still comes as a surprise that there is …

With over 450 genes, solute carriers (SLCs) constitute the largest transporter superfamily
responsible for the uptake and efflux of nutrients, metabolites, and xenobiotics in human …

Proton-coupled oligopeptide transporters (POTs) are of great pharmaceutical interest owing
to their promiscuous substrate binding site that has been linked to improved oral …

Introduction Transporters are significant in dictating drug pharmacokinetics, thus inhibition of
transporter function can alter drug concentrations resulting in drug-drug interactions (DDIs) …

Appropriate mineralization of the fetal skeleton requires an excess of phosphate in the fetus
compared to the mother. However, mechanisms for placental phosphate transport are poorly …

The glycosylphosphatidylinositol (GPI) biosynthetic pathway in the endoplasmic reticulum
(ER) is crucial for generating GPI-anchored proteins (GPI-APs), which are translocated to the …

Given the importance of solute carrier (SLC) proteins in maintaining cellular metabolic
homeostasis and that their dysregulation contributes to cancer progression, here we …

Essential amino acids as diagnostic biomarkers of hepatocellular carcinoma based on
metabolic analysis | Oncotarget Online ISSN: 1949-2553 Search: Oncotarget Home …

The autosomal dominant inherited spinocerebellar ataxias (SCAs) are a group of
neurodegenerative disorders characterized by cerebellar atrophy and loss of Purkinje …