Immunocompromised patients are highly susceptible to influenza virus infections. Although
neuraminidase inhibitor (NAI) therapy has proved effective in these patients, the treatment …

Host competence, or how well an individual transmits pathogens, varies substantially within
and among animal populations. As this variation can alter the course of epidemics and …

Despite the availability of effective preventative vaccines and potent small-molecule antiviral
drugs, effective non-toxic prophylactic and therapeutic measures are still lacking for many …

Influenza A viruses (IAV) are members of the Orthomyxoviridae family of negative-sense
RNA viruses. The greatest diversity of IAV strains is found in aquatic birds, but a subset of …

While vaccination and therapeutics for prevention/treatment of influenza are available, new
strategies are needed to combat influenza disease in susceptible populations, particularly …

Elucidating the genetic basis of influenza A viruses (IAVs) is important to understand which
mutations will determine the virulence and the host range of mammals. Here, seasonal …

In the war against the CO VID-19 pandemic, the world is experiencing severe resource
constraints. Although transmission routes are well understood, we suspect that they cause …

Influenza A virus subtype H1N1 has caused global pandemics like the “Spanish flu” in 1918
and the 2009 H1N1 pandemic several times. H1N1 remains in circulation and survives in …

Influenza virus infections can be complicated by bacterial superinfections, which are
medically relevant because of a complex interaction between the host, the virus, and the …

Background Influenza A virus causes respiratory disease in many animal species as well as
in humans. Due to the high human-animal interface, the monitoring of canine influenza in …