[HTML][HTML] Role of FKBP5 and its genetic mutations in stress-induced psychiatric disorders: an opportunity for drug discovery
M Malekpour, D Shekouh, ME Safavinia… - Frontiers in …, 2023 - frontiersin.org
Stress-induced mental health disorders are affecting many people around the world.
However, effective drug therapy for curing psychiatric diseases does not occur sufficiently …
However, effective drug therapy for curing psychiatric diseases does not occur sufficiently …
Prevalence of bullying victimisation amongst first-episode psychosis patients and unaffected controls
Background Despite increasing evidence suggesting that childhood maltreatment is
significantly associated with psychosis, the specific role of bullying in the onset of psychotic …
significantly associated with psychosis, the specific role of bullying in the onset of psychotic …
[HTML][HTML] Moderating role of FKBP5 genotype in the impact of childhood adversity on cortisol stress response during adulthood
AF Buchmann, N Holz, R Boecker, D Blomeyer… - European …, 2014 - Elsevier
Recent research suggests an important role of FKBP5, a glucocorticoid receptor regulating
co-chaperone, in the development of stress-related diseases such as depression and …
co-chaperone, in the development of stress-related diseases such as depression and …
The prospect of FKBP51 as a drug target
MV Schmidt, M Paez‐Pereda, F Holsboer… - …, 2012 - Wiley Online Library
The FK506 binding protein 51 (FKBP51) is best known as an Hsp90‐associated co‐
chaperone that regulates the responsiveness of steroid hormone receptors. In human …
chaperone that regulates the responsiveness of steroid hormone receptors. In human …
Epigenetic alterations associated with war trauma and childhood maltreatment
L Ramo‐Fernández, A Schneider… - … sciences & the law, 2015 - Wiley Online Library
Survivors of war trauma or childhood maltreatment are at increased risk for trauma‐spectrum
disorders such as post‐traumatic stress disorder (PTSD). In addition, traumatic stress has …
disorders such as post‐traumatic stress disorder (PTSD). In addition, traumatic stress has …
FKBP5 as a possible moderator of the psychosis-inducing effects of childhood trauma
D Collip, I Myin-Germeys, M Wichers… - The British Journal of …, 2013 - cambridge.org
BackgroundFK506 binding protein 5 (FKBP5) has repeatedly been shown to be a critical
determinant of post-traumatic stress disorder (PTSD) and depression following childhood …
determinant of post-traumatic stress disorder (PTSD) and depression following childhood …
Diverse structures, functions and uses of FK506 binding proteins
JM Bonner, GL Boulianne - Cellular signalling, 2017 - Elsevier
Abstract FK506 (Tacrolimus), isolated from Streptomyces tsukubaenis is a powerful
immunosuppressant shown to inhibit T cell activation. FK506 mediated immunosuppression …
immunosuppressant shown to inhibit T cell activation. FK506 mediated immunosuppression …
Biological alterations affecting risk of adult psychopathology following childhood trauma: a review of sex differences
A Tiwari, A Gonzalez - Clinical psychology review, 2018 - Elsevier
Childhood trauma exposure is a significant public health problem. While adult mental health
consequences of such experiences are well documented, sex differences in both …
consequences of such experiences are well documented, sex differences in both …
The role of hypothalamus–pituitary–adrenal genes and childhood trauma in borderline personality disorder
Current knowledge suggests that borderline personality disorder (BPD) results from the
interaction between genetic and environmental factors. Research has mainly focused on …
interaction between genetic and environmental factors. Research has mainly focused on …
GxE effects of FKBP5 and traumatic life events on PTSD: A meta-analysis
Background Twin studies have demonstrated that both genetic and environmental factors
influence risk for posttraumatic stress disorder (PTSD), and there is some evidence …
influence risk for posttraumatic stress disorder (PTSD), and there is some evidence …