Global trends in hepatocellular carcinoma epidemiology: implications for screening, prevention and therapy

AG Singal, F Kanwal, JM Llovet - Nature reviews Clinical oncology, 2023 - nature.com
Hepatocellular carcinoma (HCC) mortality rates are increasing globally, and particularly in
the Western world. Cirrhosis remains the predominant risk factor for HCC. However …

Friend or foe? The elusive role of hepatic stellate cells in liver cancer

B Cogliati, CN Yashaswini, S Wang, D Sia… - Nature Reviews …, 2023 - nature.com
Liver fibrosis is a substantial risk factor for the development and progression of liver cancer,
which includes hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma …

Nonalcoholic fatty liver disease and hepatocellular carcinoma: Insights in epidemiology, pathogenesis, imaging, prevention and therapy

SA Polyzos, L Chrysavgis, ID Vachliotis… - Seminars in cancer …, 2023 - Elsevier
Hepatocellular carcinoma (HCC) is estimated to be the third leading cause of cancer-related
mortality and is characterized by low survival rates. Nonalcoholic fatty liver disease (NAFLD) …

[HTML][HTML] Invited review liver fibrosis in NAFLD/NASH: From pathophysiology towards diagnostic and therapeutic strategies

M Parola, M Pinzani - Molecular Aspects of Medicine, 2024 - Elsevier
Liver fibrosis, as an excess deposition of extracellular matrix (ECM) components, results
from chronic liver injury as well as persistent activation of inflammatory response and of …

Precision treatment in advanced hepatocellular carcinoma

X Yang, C Yang, S Zhang, H Geng, AX Zhu… - Cancer Cell, 2024 - cell.com
The past decade has witnessed significant advances in the systemic treatment of advanced
hepatocellular carcinoma (HCC). Nevertheless, the newly developed treatment strategies …

Adjuvant and neoadjuvant immunotherapies in hepatocellular carcinoma

JM Llovet, R Pinyol, M Yarchoan, AG Singal… - Nature Reviews …, 2024 - nature.com
Liver cancer, specifically hepatocellular carcinoma (HCC), is the sixth most common cancer
and the third leading cause of cancer mortality worldwide. The development of effective …

MAFLD: an optimal framework for understanding liver cancer phenotypes

H Crane, C Gofton, A Sharma, J George - Journal of Gastroenterology, 2023 - Springer
Hepatocellular carcinoma has a substantial global mortality burden which is rising despite
advancements in tackling the traditional viral risk factors. Metabolic (dysfunction) associated …

Human diet‐derived polyphenolic compounds and hepatic diseases: From therapeutic mechanisms to clinical utilization

Q Hu, W Zhang, F Wei, M Huang, M Shu… - Phytotherapy …, 2024 - Wiley Online Library
This review focuses on the potential ameliorative effects of polyphenolic compounds derived
from human diet on hepatic diseases. It discusses the molecular mechanisms and recent …

Semaglutide reduces tumor burden in the GAN diet-induced obese and biopsy-confirmed mouse model of NASH-HCC with advanced fibrosis

HH Hansen, S Pors, MW Andersen, M Vyberg… - Scientific Reports, 2023 - nature.com
Non-alcoholic steatohepatitis (NASH) is emerging as a major cause of hepatocellular
carcinoma (HCC), however, it is not resolved if compounds in late-stage clinical …

Inflammation and digestive cancer

H Waldum, R Fossmark - International Journal of Molecular Sciences, 2023 - mdpi.com
Chronic inflammation is linked to carcinogenesis, particularly in the digestive organs, ie, the
stomach, colon, and liver. The mechanism of this effect has, however, only partly been …