Cannabinoids in the landscape of cancer

N Mangal, S Erridge, N Habib, A Sadanandam… - Journal of cancer …, 2021 - Springer
Introduction Cannabinoids are a group of terpenophenolic compounds derived from the
Cannabis sativa L. plant. There is a growing body of evidence from cell culture and animal …

Cannabidiol regulates apoptosis and autophagy in inflammation and cancer: A review

Z Fu, PY Zhao, XP Yang, H Li, SD Hu, YX Xu… - Frontiers in …, 2023 - frontiersin.org
Cannabidiol (CBD) is a terpenoid naturally found in plants. The purified compound is used
in the treatment of mental disorders because of its antidepressive, anxiolytic, and …

Cannabidiol modulation of oxidative stress and signalling

SR Pereira, B Hackett, DN O'Driscoll, MC Sun… - Neuronal …, 2021 - portlandpress.com
Cannabidiol (CBD), one of the primary non-euphoric components in the Cannabis sativa L.
plant, has undergone clinical development over the last number of years as a therapeutic for …

The cytotoxic effects of cannabidiol and cannabigerol on glioblastoma stem cells may mostly involve GPR55 and TRPV1 signalling

TT Lah, B Majc, M Novak, A Sušnik, B Breznik… - Cancers, 2022 - mdpi.com
Simple Summary In glioblastoma (GBM), the highest-grade IV glioma, members of the large
membrane receptor family of G protein-coupled receptors (GPCRs) are upregulated …

Targeting the Endocannabinoid System Present in the Glioblastoma Tumour Microenvironment as a Potential Anti-Cancer Strategy

MH Dasram, P Naidoo, RB Walker… - International Journal of …, 2024 - mdpi.com
The highly aggressive and invasive glioblastoma (GBM) tumour is the most malignant lesion
among adult-type diffuse gliomas, representing the most common primary brain tumour in …

Plant-derived cannabinoids as anticancer agents

EM O'Reilly, JM Cosgrave, WM Gallagher, AS Perry - Trends in cancer, 2022 - cell.com
Substantial preclinical evidence demonstrates the antiproliferative, cytotoxic, and
antimetastatic properties of plant-derived cannabinoids (phytocannabinoids) such as …

Cannabinoids in the treatment of glioblastoma

B Buchalska, K Kamińska, M Owe-Larsson… - Pharmacological …, 2024 - Springer
Glioblastoma (GBM) is the most prevalent primary malignant tumor of the nervous system.
While the treatment of other neoplasms is increasingly more efficacious the median survival …

Anti-proliferative and apoptotic effect of cannabinoids on human pancreatic ductal adenocarcinoma xenograft in BALB/c nude mice model

TQ Le, N Meesiripan, S Sanggrajang… - Scientific Reports, 2024 - nature.com
Human pancreatic ductal adenocarcinoma (PDAC) is a highly malignant and lethal tumor of
the exocrine pancreas. Cannabinoids extracted from the hemp plant Cannabis sativa have …

Elucidation of GPR55-Associated Signaling behind THC and LPI Reducing Effects on Ki67-Immunoreactive Nuclei in Patient-Derived Glioblastoma Cells

MR Kolbe, T Hohmann, U Hohmann, E Maronde… - Cells, 2023 - mdpi.com
GPR55 is involved in many physiological and pathological processes. In cancer, GPR55 has
been described to show accelerating and decelerating effects in tumor progression resulting …

NIR-II emissive aza-BODIPY-based nanoparticles for triggering glioblastoma apoptosis in brain

M Gao, Z Cui, Y Shen, Y Li, D Zhang, X Gao… - Chinese Chemical …, 2024 - Elsevier
ABSTRACT D-D'-A type aza-borondipyrromethenes (aza-BODIPYs) were prepared by
Suzuki cross-coupling reaction. Photothermal conversion efficiency of self-assemble aza …