Colorectal cancer (CRC), the third most common type of cancer, is the second leading cause
of cancer-related mortality rates worldwide. Although modern research was able to shed …

Nuclear protein in testis (NUT) carcinoma is a rare, highly aggressive, poorly differentiated
carcinoma occurring mostly in adolescents and young adults. This tumor usually arises from …

Delineating how chromosomes fold at length scales beyond one megabase remains
obscure relative to smaller-scale folding into TADs, loops, and nucleosomes. We find that …

To investigate the mechanism that drives dramatic mistargeting of active chromatin in NUT
midline carcinoma (NMC), we have identified protein interactions unique to the BRD4–NUT …

Recurrent chromosomal rearrangements leading to the generation of oncogenic fusion
proteins are a common feature of many cancers. These aberrations are particularly …

Poorly differentiated neoplasms lacking characteristic histopathologic features represent a
significant challenge to the pathologist for diagnostic classification. Classically, NUT …

Structural alterations of NUTM1 were originally thought to be restricted to poorly
differentiated carcinomas with variable squamous differentiation originating in the midline …

Numerous cellular processes occur in the context of condensates, a type of large,
membrane-less biomolecular assembly generated through phase separation. These …

NUT carcinoma and thoracic SMARCA4‐deficient undifferentiated tumour are unique
entities in the 5th edition of the World Health Organisation (WHO) Classification of Thoracic …

The establishment, maintenance and dynamic regulation of three-dimensional (3D)
chromatin structures provide an important means for partitioning of genome into functionally …