Biologically active quinoline and quinazoline alkaloids part I

XF Shang, SL Morris‐Natschke, YQ Liu… - Medicinal research …, 2018 - Wiley Online Library
Quinoline and quinazoline alkaloids, two important classes of N‐based heterocyclic
compounds, have attracted tremendous attention from researchers worldwide since the 19th …

Synthetic and medicinal perspective of quinolines as antiviral agents

R Kaur, K Kumar - European Journal of Medicinal Chemistry, 2021 - Elsevier
In current scenario, various heterocycles have come up exhibiting crucial role in various
medicinal agents which are valuable for mankind. Out of diverse range of heterocycle …

Recent advances of the Povarov reaction in medicinal chemistry

O Ghashghaei, C Masdeu, C Alonso, F Palacios… - Drug Discovery Today …, 2018 - Elsevier
The Povarov multicomponent reaction consists on the condensation of an aniline, an
aldehyde, and an activated olefin to generate a tetrahydroquinoline adduct with 3 diversity …

Quinoline heterocyclic containing plant and marine candidates against drug-resistant Mycobacterium tuberculosis: A systematic drug-ability investigation

SS Swain, S Pati, T Hussain - European Journal of Medicinal Chemistry, 2022 - Elsevier
Today, tuberculosis (TB) caused by the acid-fast bacilli, Mycobacterium tuberculosis (Mtb) is
the most infectious killer disease globally with high morbidity and mortality rates. The rapid …

Ultrasound-assisted transition-metal-free catalysis: a sustainable route towards the synthesis of bioactive heterocycles

B Borah, LR Chowhan - RSC advances, 2022 - pubs.rsc.org
Heterocycles of synthetic and natural origin are a well-established class of compounds
representing a broad range of organic molecules that constitute over 60% of drugs and …

4‐Hydroxycoumarin: A versatile substrate for transition‐metal‐free multicomponent synthesis of bioactive heterocycles

B Borah, K Dhar Dwivedi… - Asian Journal of Organic …, 2021 - Wiley Online Library
One‐pot multi‐component reactions especially under transition‐metal‐free catalysis served
as an efficient, and environmentally friendly method for the construction of value‐added …

Regioselective Functionalization of Quinolines through CH Activation: A Comprehensive Review

A Corio, C Gravier-Pelletier, P Busca - Molecules, 2021 - mdpi.com
Quinoline is a versatile heterocycle that is part of numerous natural products and countless
drugs. During the last decades, this scaffold also became widely used as ligand in …

N-, O- and S-Heterocycles Synthesis in Deep Eutectic Solvents

S Perrone, F Messa, L Troisi, A Salomone - Molecules, 2023 - mdpi.com
The synthesis of heterocycles is a fundamental area of organic chemistry that offers
enormous potential for the discovery of new products with important applications in our daily …

Palladium catalyzed radical relay for the oxidative cross-coupling of quinolines

X Zhao, X Zhu, K Wang, J Lv, S Chen, G Yao… - Nature …, 2022 - nature.com
Traditional approaches for transition-metal catalyzed oxidative cross-coupling reactions rely
on sp 2-hybridized starting materials, such as aryl halides, and more specifically …

Ultrasound assisted synthesis of 5–7 membered heterocyclic rings in organic molecules

G Shabir, I Shafique, A Saeed - Journal of Heterocyclic …, 2022 - Wiley Online Library
Ultrasound synthesis is a powerful technique that is being used increasingly to accelerate
organic reactions as a green synthetic approach. Ultrasonication has offered advantages …