Central regulation of food intake is a key mechanism contributing to energy homeostasis.
Many neural circuits that are thought to orchestrate feeding behavior overlap with the brain's …

The worldwide prevalence of obesity and type 2 diabetes mellitus (T2DM) continues to rise
at an alarming pace. Recently the potential role of the gut microbiome in these metabolic …

The dorsal raphe nucleus (DRN) is involved in organizing reward-related behaviours;
however, it remains unclear how genetically defined neurons in the DRN of a freely …

Regulating how fast to learn is critical for flexible behavior. Learning about the
consequences of actions should be slow in stable environments, but accelerate when that …

It is now nearly 5 years since the last of the currently recognised 5-HT receptors was
identified in terms of its cDNA sequence. Over this period, much effort has been directed …

Abstract Serotonin (5-hydroxytryptamine or 5-HT) is a multifunctional bioamine with
important signaling roles in a range of physiological pathways. Almost all of the 5-HT in our …

Individuals with anorexia nervosa have a relentless preoccupation with dieting and weight
loss that results in severe emaciation and sometimes death. It is controversial whether such …

Serotonin has been implicated in the control of satiety for almost four decades. Historically,
the insight that the appetite suppressant effect of fenfluramine is linked to serotonin has …

Serotonin (5-hydroxytryptamine, 5-HT) was identified initially as the active substance from
brain extracts that produced peripheral vasoconstriction (Rapport et al 1948). This …

Anorexia nervosa (AN) and bulimia nervosa (BN) are related disorders of unknown etiology
that most commonly begin during adolescence in women. AN and BN have unique and …