Our current knowledge of human memory CD8+ T cells is derived largely from studies of the
intravascular space. However, emerging data are starting to challenge some of the dogmas …

The use of genomics is firmly established in clinical practice, resulting in innovations across
a wide range of disciplines such as genetic screening, rare disease diagnosis and …

T cells are the central drivers of many inflammatory diseases, but the repertoire of tissue-
resident T cells at sites of pathology in human organs remains poorly understood. We …

Hematopoietic stem cell transplantation is an effective regenerative therapy for many
malignant, inherited, or autoimmune diseases. However, our understanding of reconstituted …

The challenge of eradicating leukemia in patients with acute myelogenous leukemia (AML)
after initial cytoreduction has motivated modern efforts to combine synergistic active …

Polarized T helper cell (Th cell) responses are important determinants of host protection. Th
cell subsets tailor their functional repertoire of cytokines to their cognate antigens to …

Memory T cells form an essential part of immunological memory, which can last for years or
even a lifetime. Much experimental work has shown that the individual cells that make up the …

The human skin is populated by a diverse pool of memory T cells, which can act rapidly in
response to pathogens and cancer antigens. Tissue‐resident memory T cells (TRM) have …

Rheumatoid arthritis (RA) is a highly disabling, systemic autoimmune disease. It presents a
remarkable tendency to recur, which renders it almost impossible for patients to live without …

Notch signaling promotes T cell pathogenicity and graft-versus-host disease (GVHD) after
allogeneic hematopoietic cell transplantation (allo-HCT) in mice, with a dominant role for the …