Abstract Type 2 diabetes (T2D) is a widely prevalent disease with substantial economic and
social impact for which multiple conventional and novel pharmacotherapies are currently …

This narrative review highlights current evidence linking greater body fatness to risk of
various cancers, with focus on evidence from recent large cohort studies and pooled …

Insulin action is impaired in type 2 diabetes. The functions of the hormone are an integrated
product of insulin secretion from pancreatic β-cells and insulin clearance by receptor …

Obesity, which has currently reached pandemic dimensions, is usually accompanied by
diabetes mellitus type 2 (T2DM). These two conditions share common pathophysiological …

Recent data suggests that (pre) diabetes onset is preceded by a period of hyperinsulinemia.
Consumption of the “modern” Western diet, over-nutrition, genetic background, decreased …

The close relationship between the metabolic syndrome (MetS) and nonalcoholic fatty liver
disease (NAFLD) is well described in the literature. 1, 2 Indeed, due to this strong …

Dysfunctional signaling in midbrain reward circuits perpetuates diseases characterized by
compulsive overconsumption of rewarding substances such as substance abuse, binge …

Insulin resistance (IR), designated as the blunted response of insulin target tissues to
physiological level of insulin, plays crucial roles in the development and progression of …

The past decade has witnessed increasing evidence for a crucial role played by glial cells,
notably astrocytes, in Alzheimer's disease (AD). To provide novel insights into the roles of …

Glucose-sensitive microneedle systems (GSMSs) as an intelligent strategy for treating
diabetes can well solve the problems of puncture pain, hypoglycemia, skin damage, and …