The causal mechanisms and treatment for the negative symptoms and cognitive dysfunction
in schizophrenia are the main issues attracting the attention of psychiatrists over the last …

Background Patients with schizophrenia display peripheral inflammation but the impact of
illness phase is not clear. Our meta-analysis investigated the difference in CRP levels …

Promising research investigating the association between inflammatory biomarkers and
response to antipsychotic and/or adjunctive therapy, observed by improvement in psychiatric …

The negative symptoms of schizophrenia are an unmet treatment target as currently
approved treatments mostly control positive symptoms. The persistence of these symptoms …

Introduction: Schizophrenia is a debilitating condition with three main symptom domains:
positive, negative, and cognitive. Approximately one-third of persons with schizophrenia will …

The glucose metabolism in the pentose cycle is essential to the source of NADPH.
Deficiency of these enzymes have been linked to depression and psychotic disorders …

Background Oxidative stress (OS) and neuroinflammatory pathways play an important role
in the pathophysiology of schizophrenia. The present study investigated the relationship …

Background Low-grade inflammation and altered inflammatory markers have been
observed in treatment-resistant schizophrenia (TRS). Interleukin-6 (IL-6) is one of the pro …

Abstract Paraoxonase-I (PON1) is a calcium-dependent hydrolytic enzyme, plays an
important role in most antioxidant properties related to high-density lipoprotein (HDL) …

Studies investigating the association between IL-6/IL-6R axis and schizophrenia (SZ)
susceptibility found inconsistent data. To reconcile the results, a systematic review followed …