Sepsis is a common condition that is associated with unacceptably high mortality and, for
many of those who survive, long-term morbidity. Increased awareness of the condition …

Background Supplemental oxygen is often administered liberally to acutely ill adults, but the
credibility of the evidence for this practice is unclear. We systematically reviewed the efficacy …

Background Invasive mechanical ventilation in critically ill adults involves adjusting the
fraction of inspired oxygen to maintain arterial oxygen saturation. The oxygen-saturation …

Significance: Under homeostatic conditions, the endothelium dynamically regulates vascular
barrier function, coagulation pathways, leukocyte adhesion, and vasomotor tone. During …

Background The joint committee of the Japanese Society of Intensive Care
Medicine/Japanese Respiratory Society/Japanese Society of Respiratory Care Medicine on …

Pulmonary infection is one of the main complications occurring in patients suffering from
acute respiratory distress syndrome (ARDS). Besides traditional risk factors, dysregulation of …

Early management of sepsis and septic shock is crucial for patients' prognosis. As the
Emergency Department (ED) is the place where the first medical contact for septic patients is …

Importance Hyperoxemia may increase organ dysfunction in critically ill patients, but optimal
oxygenation targets are unknown. Objective To determine whether a low-normal Pao 2 …

Current achievements in medical science and technological advancements in intensive care
medicine have allowed better support of critically ill patients in intensive care units (ICUs) …

Sepsis-associated encephalopathy is a severe neurologic syndrome characterized by a
diffuse dysfunction of the brain caused by sepsis. This review provides a concise overview of …