Therapeutic insights on ferroptosis in Parkinson's disease
Parkinson's disease (PD) is a neurodegenerative disorder that alters either motor or non-
motor activities. Dopamine-based medications can help alleviate symptoms at an early …
motor activities. Dopamine-based medications can help alleviate symptoms at an early …
Therapeutic implications of cyclooxygenase (COX) inhibitors in ischemic injury
Introduction Ischemia–reperfusion injury (IRI) is the inexplicable aggravation of cellular
dysfunction that results in blood flow restoration to previously ischemic tissues. COX …
dysfunction that results in blood flow restoration to previously ischemic tissues. COX …
α-Lipoic acid, an organosulfur biomolecule a novel therapeutic agent for neurodegenerative disorders: an mechanistic perspective
Abstract Lipoic acid (α-LA)(1, 2-dithiolane3-pentanoic acid (C8H14O2S2) is also called
thioctic acid with an oxidized (disulfide, LA) and a reduced (di-thiol: dihydro-lipoic acid …
thioctic acid with an oxidized (disulfide, LA) and a reduced (di-thiol: dihydro-lipoic acid …
Therapeutic and mechanistic intervention of vitamin D in neuropsychiatric disorders
Vitamin D deficiency is believed to affect between 35 and 55% of the world's population,
making it a hidden pandemic. In addition to its role in bone and calcium homeostasis …
making it a hidden pandemic. In addition to its role in bone and calcium homeostasis …
Caspase-mediated regulation of the distinct signaling pathways and mechanisms in neuronal survival
H Khan, A Bangar, AK Grewal, P Bansal… - International …, 2022 - Elsevier
Caspases are intimately associated with altering various signaling pathways, resulting in
programmed cell death or apoptosis. Apoptosis is necessary for the normal homeostasis of …
programmed cell death or apoptosis. Apoptosis is necessary for the normal homeostasis of …
Targeting ferroptosis in ischemia/reperfusion renal injury
Renal I/R injury is a severe medical condition contributing to acute kidney injury (AKI),
leading to rapid kidney dysfunction and high mortality rates. It is generally observed during …
leading to rapid kidney dysfunction and high mortality rates. It is generally observed during …
Understanding mechanistic aspect of the therapeutic role of herbal agents on neuroplasticity in cerebral ischemic-reperfusion injury
Ethnopharmacological relevance Stroke is one of the leading causes of death and disability.
The only FDA-approved therapy for treating stroke is tissue plasminogen activator (tPA) …
The only FDA-approved therapy for treating stroke is tissue plasminogen activator (tPA) …
Therapeutic implications of sonic hedgehog pathway in metabolic disorders: Novel target for effective treatment
Hedgehog, a developmental morphogen, and its downstream signalling have recently been
associated with metabolic control. Sonic hedgehog signalling (Shh) is a significant pathway …
associated with metabolic control. Sonic hedgehog signalling (Shh) is a significant pathway …
Emerging targets for modulation of immune response and inflammation in stroke
The inflammatory and immunological responses play a significant role after stroke. The
innate immune activation stimulated by microglia during stroke results in the migration of …
innate immune activation stimulated by microglia during stroke results in the migration of …
Therapeutic implications of phosphorylation-and dephosphorylation-dependent factors of cAMP-response element-binding protein (CREB) in neurodegeneration
Neurodegeneration is a condition of the central nervous system (CNS) characterized by loss
of neural structures and function. The most common neurodegenerative disorders (NDDs) …
of neural structures and function. The most common neurodegenerative disorders (NDDs) …