Gene expression is controlled in a dynamic and regulated manner to allow for the consistent
and steady expression of some proteins as well as the rapidly changing production of other …

BACKGROUND Genes correspond to single transcription units, starting from the promoter
and ending at the terminator. Terminating gene transcription is directly coupled to mRNA …

The torpedo model of transcription termination asserts that the exonuclease Xrn2 attacks the
5′ PO 4-end exposed by nascent RNA cleavage and chases down the RNA polymerase …

The allosteric and torpedo models have been used for 30 yr to explain how transcription
terminates on protein-coding genes. The former invokes termination via conformational …

RNA polymerase II (Pol II) transcribes hundreds of thousands of transcription units–a
reaction always brought to a close by its termination. Because Pol II transcribes multiple …

Termination is a ubiquitous phase in every transcription cycle but is incompletely understood
and a subject of debate. We used gene editing as a new approach to address its mechanism …

The synthesis of nascent RNA is a discontinuous process in which phases of productive
elongation by RNA polymerase are interrupted by frequent pauses. Transcriptional pausing …

Summary RNA polymerase II (RNAPII) transcription involves initiation from a promoter,
transcriptional elongation through the gene, and termination in the terminator region. In …

At the end of protein-coding genes, RNA polymerase (Pol) II undergoes a concerted
transition that involves 3′-processing of the pre-mRNA and transcription termination. Here …

Transcription initiates pervasively in all organisms, which challenges the notion that the
information to be expressed is selected mainly based on mechanisms defining where and …