Involvement of inflammasomes in tumor microenvironment and tumor therapies
Z Zhang, X Li, Y Wang, Y Wei, X Wei - Journal of Hematology & Oncology, 2023 - Springer
Inflammasomes are macromolecular platforms formed in response to damage-associated
molecular patterns (DAMPs) and pathogen-associated molecular patterns, whose formation …
molecular patterns (DAMPs) and pathogen-associated molecular patterns, whose formation …
The IL-18/IL-18R1 signalling axis: Diagnostic and therapeutic potential in hypertension and chronic kidney disease
Chronic kidney disease (CKD) is inherently an inflammatory condition, which ultimately
results in the development of end stage renal disease or cardiovascular events. Low-grade …
results in the development of end stage renal disease or cardiovascular events. Low-grade …
[HTML][HTML] Podocyte-specific Nlrp3 inflammasome activation promotes diabetic kidney disease
K Shahzad, S Fatima, H Khawaja, A Elwakiel, I Gadi… - Kidney International, 2022 - Elsevier
Efficient therapies for diabetic kidney disease (DKD), now the leading cause of kidney
failure, are lacking. One hallmark of DKD is sterile inflammation (inflammation in absence of …
failure, are lacking. One hallmark of DKD is sterile inflammation (inflammation in absence of …
MCC950 in the treatment of NLRP3-mediated inflammatory diseases: Latest evidence and therapeutic outcomes
S Bakhshi, S Shamsi - International Immunopharmacology, 2022 - Elsevier
Evidence suggests that various innate immune system components are involved in
pathological inflammatory conditions. Among these components, the NLR family pyrin …
pathological inflammatory conditions. Among these components, the NLR family pyrin …
Cannabinoids as key regulators of inflammasome signaling: a current perspective
Inflammasomes are cytoplasmic inflammatory signaling protein complexes that detect
microbial materials, sterile inflammatory insults, and certain host-derived elements …
microbial materials, sterile inflammatory insults, and certain host-derived elements …
NLRP3 inflammasome-mediated neuroinflammation and related mitochondrial impairment in Parkinson's disease
QQ Han, W Le - Neuroscience Bulletin, 2023 - Springer
Parkinson's disease (PD) is a common neurodegenerative disorder caused by the loss of
dopamine neurons in the substantia nigra and the formation of Lewy bodies, which are …
dopamine neurons in the substantia nigra and the formation of Lewy bodies, which are …
NLRP3 inflammasomes: a potential target to improve mitochondrial biogenesis in parkinson's disease
Parkinson's disease (PD) is a common neurodegenerative condition for which no approved
treatment exists to prevent collective neuronal death. There is ample evidence that …
treatment exists to prevent collective neuronal death. There is ample evidence that …
Key mechanisms and potential targets of the NLRP3 inflammasome in neurodegenerative diseases
Y Guan, F Han - Frontiers in Integrative Neuroscience, 2020 - frontiersin.org
Neurodegenerative diseases are neuronal disorders characterized by the loss of a large
number of neurons in the human brain. Innate immunity-mediated neuroinflammation …
number of neurons in the human brain. Innate immunity-mediated neuroinflammation …
Role of microgliosis and NLRP3 inflammasome in Parkinson's disease pathogenesis and therapy
FM de Araújo, L Cuenca-Bermejo… - Cellular and Molecular …, 2022 - Springer
Parkinson's disease (PD) is a neurodegenerative disorder marked primarily by motor
symptoms such as rigidity, bradykinesia, postural instability and resting tremor associated …
symptoms such as rigidity, bradykinesia, postural instability and resting tremor associated …
Biochanin A Ameliorates Nephropathy in High-Fat Diet/Streptozotocin-Induced Diabetic Rats: Effects on NF-kB/NLRP3 Axis, Pyroptosis, and Fibrosis
Nephropathy is the most prevalent microvascular disorder in diabetes mellitus. Oxidative
stress and inflammatory cascade provoked by the persistent hyperglycemic milieu play …
stress and inflammatory cascade provoked by the persistent hyperglycemic milieu play …