Inflammasomes are macromolecular platforms formed in response to damage-associated
molecular patterns (DAMPs) and pathogen-associated molecular patterns, whose formation …

Chronic kidney disease (CKD) is inherently an inflammatory condition, which ultimately
results in the development of end stage renal disease or cardiovascular events. Low-grade …

Efficient therapies for diabetic kidney disease (DKD), now the leading cause of kidney
failure, are lacking. One hallmark of DKD is sterile inflammation (inflammation in absence of …

Evidence suggests that various innate immune system components are involved in
pathological inflammatory conditions. Among these components, the NLR family pyrin …

Inflammasomes are cytoplasmic inflammatory signaling protein complexes that detect
microbial materials, sterile inflammatory insults, and certain host-derived elements …

Parkinson's disease (PD) is a common neurodegenerative disorder caused by the loss of
dopamine neurons in the substantia nigra and the formation of Lewy bodies, which are …

Parkinson's disease (PD) is a common neurodegenerative condition for which no approved
treatment exists to prevent collective neuronal death. There is ample evidence that …

Neurodegenerative diseases are neuronal disorders characterized by the loss of a large
number of neurons in the human brain. Innate immunity-mediated neuroinflammation …

Parkinson's disease (PD) is a neurodegenerative disorder marked primarily by motor
symptoms such as rigidity, bradykinesia, postural instability and resting tremor associated …

Nephropathy is the most prevalent microvascular disorder in diabetes mellitus. Oxidative
stress and inflammatory cascade provoked by the persistent hyperglycemic milieu play …