Cellular and molecular pathobiology of heart failure with preserved ejection fraction

S Mishra, DA Kass - Nature Reviews Cardiology, 2021 - nature.com
Heart failure with preserved ejection fraction (HFpEF) affects half of all patients with heart
failure worldwide, is increasing in prevalence, confers substantial morbidity and mortality …

The role of systemic microvascular dysfunction in heart failure with preserved ejection fraction

J Weerts, SGJ Mourmans, A Barandiaran Aizpurua… - Biomolecules, 2022 - mdpi.com
Heart failure with preserved ejection fraction (HFpEF) is a condition with increasing
incidence, leading to a health care problem of epidemic proportions for which no curative …

Targeting fibrosis in the failing heart with nanoparticles

F Passaro, CG Tocchetti, G Spinetti, F Paudice… - Advanced Drug Delivery …, 2021 - Elsevier
Heart failure (HF) is a clinical syndrome characterized by typical symptoms and signs
caused by a structural and/or functional cardiac abnormality, resulting in a reduced cardiac …

A potential role of autophagy-mediated vascular senescence in the pathophysiology of HFpEF

F Sanhueza-Olivares, MF Troncoso… - Frontiers in …, 2022 - frontiersin.org
Heart failure with preserved ejection fraction (HFpEF) is one of the most complex and most
prevalent cardiometabolic diseases in aging population. Age, obesity, diabetes, and …

The impact of heart failure therapy in patients with mildly reduced ejection fraction: a network meta‐analysis

M Leite, F Sampaio, FA Saraiva, SO Diaz… - ESC Heart …, 2023 - Wiley Online Library
Background Recent heart failure (HF) guidelines have re‐classified HF patients with left
ventricular ejection fraction (LVEF) between 41% and 49% as HF with mildly reduced …

[HTML][HTML] Effects of different exercise programs on the cardiorespiratory reserve in HFpEF patients: a systematic review and meta-analysis

A Boulmpou, MP Theodorakopoulou, AK Boutou… - Hellenic Journal of …, 2022 - Elsevier
HFpEF represents a heterogeneous syndrome with complex pathophysiological substrates
and multiple clinical manifestations. Recently, much attention has been focused on cardiac …

Heart failure with preserved ejection fraction is the most frequent but commonly overlooked phenotype in patients on chronic hemodialysis

J Malik, A Valerianova, SS Pesickova… - Frontiers in …, 2023 - frontiersin.org
Introduction Heart failure (HF) is a serious complication of end-stage kidney disease
(ESKD). However, most data come from retrospective studies that included patients on …

Coronary flow, left ventricular contractile and heart rate reserve in non-ischemic heart failure

CB Daros, Q Ciampi, L Cortigiani, N Gaibazzi… - Journal of Clinical …, 2021 - mdpi.com
Background: Left ventricular contractile reserve (LVCR), coronary flow velocity reserve
(CFVR), and heart rate reserve (HRR) affect outcome in heart failure (HF). They can be …

Periplocin Alleviates Cardiac Remodeling in DOCA-Salt–Induced Heart Failure Rats

J Hao, L Chang, D Wang, C Ji, S Zhang, Y Hou… - Journal of …, 2023 - Springer
Heart failure with preserved ejection fraction (HFpEF) is a common public health problem
associated with increased morbidity and long-term mortality. However, effective treatment for …

[HTML][HTML] Searching for an experimental rodent model of heart failure with preserved ejection fraction: Re-visited

M Jasińska-Stroschein - Biomedicine & Pharmacotherapy, 2022 - Elsevier
Heart failure with preserved ejection fraction (HFpEF) currently accounts for over 50% of all
heart failure cases. It displays a large number of comorbidities, and the pathophysiological …