Inflammation, epigenetics, and metabolism converge to cell senescence and ageing: the regulation and intervention

X Zhu, Z Chen, W Shen, G Huang, JM Sedivy… - Signal transduction and …, 2021 - nature.com
Remarkable progress in ageing research has been achieved over the past decades.
General perceptions and experimental evidence pinpoint that the decline of physical …

Inflammaging and oxidative stress in human diseases: from molecular mechanisms to novel treatments

L Zuo, ER Prather, M Stetskiv, DE Garrison… - International journal of …, 2019 - mdpi.com
It has been proposed that a chronic state of inflammation correlated with aging known as
inflammaging, is implicated in multiple disease states commonly observed in the elderly …

Age and age-related diseases: role of inflammation triggers and cytokines

IM Rea, DS Gibson, V McGilligan… - Frontiers in …, 2018 - frontiersin.org
Cytokine dysregulation is believed to play a key role in the remodeling of the immune
system at older age, with evidence pointing to an inability to fine-control systemic …

A proinflammatory gut microbiota increases systemic inflammation and accelerates atherosclerosis

E Brandsma, NJ Kloosterhuis, M Koster… - Circulation …, 2019 - Am Heart Assoc
Rationale: Several studies have suggested a role for the gut microbiota in inflammation and
atherogenesis. A causal relation relationship between gut microbiota, inflammation, and …

[HTML][HTML] Pleotropic effects of polyphenols in cardiovascular system

T Behl, S Bungau, K Kumar, G Zengin, F Khan… - Biomedicine & …, 2020 - Elsevier
Numerous epidemiological and clinical studies demonstrate the beneficial effects of
naturally occurring, polyphenol supplementations, on cardiovascular system. The present …

Inflammation, not cholesterol, is a cause of chronic disease

A Tsoupras, R Lordan, I Zabetakis - Nutrients, 2018 - mdpi.com
Since the Seven Countries Study, dietary cholesterol and the levels of serum cholesterol in
relation to the development of chronic diseases have been somewhat demonised. However …

Food anthocyanins: Malvidin and its glycosides as promising antioxidant and anti-inflammatory agents with potential health benefits

A Merecz-Sadowska, P Sitarek, T Kowalczyk, K Zajdel… - Nutrients, 2023 - mdpi.com
Anthocyanins are flavonoid compounds that are abundantly present in fruits and vegetables.
These compounds contribute to the color of these foods and offer various health benefits to …

Macrophages and foam cells: Brief overview of their role, linkage, and targeting potential in atherosclerosis

AV Poznyak, NG Nikiforov, AV Starodubova… - Biomedicines, 2021 - mdpi.com
Atherosclerosis is still one of the main causes of death around the globe. This condition
leads to various life-threatening cardiovascular complications. However, no effective …

[HTML][HTML] GLP-1 receptor agonists and reduction of cardiometabolic risk: Potential underlying mechanisms

M Rizzo, D Nikolic, AM Patti, C Mannina… - … et Biophysica Acta (BBA …, 2018 - Elsevier
Type 2 diabetes mellitus (T2DM) is a metabolic condition with an elevated impact on
cardiovascular (CV) risk. The innovative therapeutic approaches for T2DM-incretin-based …

Ferulic, sinapic, 3, 4-dimethoxycinnamic acid and indomethacin derivatives with antioxidant, anti-inflammatory and hypolipidemic functionality

P Theodosis-Nobelos, G Papagiouvannis, EA Rekka - Antioxidants, 2023 - mdpi.com
A series of thiomorpholine and cinnamyl alcohol derivatives, conjugated with cinnamic acid-
containing moieties, such as ferulic acid, sinapic acid and 3, 4-dimethoxycinnamic acid …