Carbohydrates—namely glycans—decorate every cell in the human body and most secreted
proteins. Advances in genomics, glycoproteomics and tools from chemical biology have …

The high selectivity and affinity of antibodies toward their antigens have made them a highly
valuable tool in disease therapy, diagnosis, and basic research. A plethora of chemical and …

Glycans modify lipids and proteins to mediate inter-and intramolecular interactions across all
domains of life. RNA is not thought to be a major target of glycosylation. Here, we challenge …

Currently approved immune checkpoint inhibitor therapies targeting the PD-1 and CTLA-4
receptor pathways are powerful treatment options for certain cancers; however, most …

The complexity, diversity, and heterogeneity of tumors seriously undermine the therapeutic
potential of treatment. Therefore, the current trend in clinical research has gradually shifted …

Molecular proximity orchestrates biological function, and blocking existing proximities is an
established therapeutic strategy. By contrast, strengthening or creating neoproximity with …

Cancer is one of the leading causes of morbidity and mortality in the world, but more cancer
therapies are needed to complement existing regimens due to problems of existing cancer …

Abstract Changes in glycosylation during tumour progression are a key hallmark of cancer.
One of the glycan moieties generally overexpressed in cancer are sialic acids, which can …

Sialic acid–binding immunoglobulin-type lectins (Siglecs) are expressed on the majority of
white blood cells of the immune system and play critical roles in immune cell signaling …

Upregulation of sialyltransferases—the enzymes responsible for the addition of sialic acid to
growing glycoconjugate chains—and the resultant hypersialylation of up to 40–60% of …