Reperfusion injury, the paradoxical tissue response that is manifested by blood flow-
deprived and oxygen-starved organs following the restoration of blood flow and tissue …

Acute myocardial infarction (AMI) is a leading cause of morbidity and mortality. Reperfusion
strategies are the current standard therapy for AMI. However, they may result in paradoxical …

The heart consumes circulating nutrients to fuel lifelong contraction, but a comprehensive
mapping of human cardiac fuel use is lacking. We used metabolomics on blood from artery …

Coronary artery disease (CAD) is a well‐known pathological condition that is characterized
by high morbidity and mortality. The main pathological manifestation of CAD is myocardial …

The complexity of human DNA has been affected by aerobic metabolism, including
endurance exercise and oxygen toxicity. Aerobic endurance exercise could play an …

Since the initial description of the phenomenon by Jennings et al 50 years ago, our
understanding of the underlying mechanisms of reperfusion injury has grown significantly …

The prototypical xanthine oxidase (XO) inhibitor allopurinol, has been the cornerstone of the
clinical management of gout and conditions associated with hyperuricemia for several …

There is substantial evidence that oxidative stress participates in the pathophysiology of
cardiovascular disease. Biochemical, molecular and pharmacological studies further …

Providing a comprehensive review of reactions of oxidation for different classes of organic
compounds and polymers, and biological processes mediated by free radicals, Oxidation …

While timely reperfusion of acute ischemic myocardium is essential for myocardial salvage,
reperfusion results in a unique form of myocardial damage. Functional alterations occur …