Neutrophil constitutive death is a critical cellular process for modulating neutrophil number
and function, and it plays an essential role in neutrophil homeostasis and the resolution of …

Neutrophils are peripheral immune cells that represent the first recruited innate immune
defense against infections and tissue injury. However, these cells can also induce …

Elevating Akt activation is an obvious clinical strategy to prevent progressive neuronal death
in neurological diseases. However, this endeavor has been hindered because of the lack of …

Myeloid-derived suppressor cells (MDSCs) potently suppress the anti-tumor immune
responses and also orchestrate the tumor microenvironment that favors tumor angiogenesis …

LPS stimulation of monocytes/macrophages induces the expression of genes encoding
proinflammatory cytokines and the procoagulant protein, tissue factor. Induction of these …

NETs serve to ensnare and kill microbial pathogens. However, NETs can at the same time
contribute to tissue damage and excessive inflammation. Nicotine is a major toxic agent and …

Precise control of the neutrophil death program provides a balance between their defense
functions and safe clearance, whereas impaired regulation of neutrophil death is thought to …

Caspase-3–mediated spontaneous death in neutrophils is a prototype of programmed cell
death and is critical for modulating physiopathological inflammatory responses; however …

Neutrophil chemotaxis plays an essential role in innate immunity, but the underlying cellular
mechanism is still not fully characterized. Here, using a small-molecule functional screening …

ABSTRACT Introduction: The phosphatidylinositide 3-kinase/AKT/mammalian target of
rapamycin (PI3K/AKT/mTOR) signaling pathway has emerged as an important target in …