Interictal electroencephalography (EEG) potentials in focal epilepsies are sustained by
synchronous paroxysmal membrane depolarization generated by assemblies of …

Neuronal activity in the brain reflects an excitation–inhibition balance that is regulated
predominantly by glutamatergic and GABAergic neurotransmission, and often disturbed in …

The majority of patients showing neuronal migration disorders in cortical structures suffer
from pharmaco‐resistant epilepsy. In order to study the molecular and cellular mechanisms …

Dysfunction of the LIS1 gene causes lissencephaly, a drastic neurological disorder
characterized by a deep disruption of the cortical structure. We aim to uncover alterations of …

During the perinatal period, the brain is highly vulnerable to hypoxia and inflammation,
which often cause white matter injury and long-term neuronal dysfunction such as motor and …

Hyperpolarization-activated, cyclic nucleotide-gated, nonspecific cation (HCN) channels
have a well-characterized role in regulation of cellular excitability and network activity. The …

Background: Synchronized activity of neuronal cell populations in the brain is regulated by
excitatory and inhibitory postsynaptic activity. Glutamate is the main excitatory …

The involvement of NMDA receptor subunit, NR1, with kindling phenomenon has been
reported, but the role of NR1 in epileptogenesis is still unknown. We have examined the …

Stimulus-induced pattern of bioelectric activity in human neocortical tissue was investigated
by use of the voltage sensitive dye RH795 and a fast optical recording system. During …

Disinhibition of the cortex (eg, by GABA-receptor blockade) generates synchronous and
oscillatory electrophysiological activity that propagates along the cortex. We have studied, in …