Background Preventive therapy is a risk reduction option for women who have an increased
risk of breast cancer. The effectiveness of preventive therapy to reduce breast cancer …

Genetic testing may enable early disease detection, targeted surveillance, and result in
effective prevention strategies. Knowledge of genetic risk may also enable behavioral …

Several options for cancer prevention are available for women with a BRCA1 or BRCA2
mutation, including prophylactic surgery, chemoprevention and screening. The authors …

Several commentators have argued that these problems might be avoided by obtaining, at
the time samples are collected, a 1-time general consent for research. 3, 4 Although 1-time …

Abstract BACKGROUND: For BRCA1/BRCA2 gene testing to benefit public health, mutation
carriers must initiate appropriate risk management strategies. There has been little research …

It has been suggested that a personalised approach to cancer prevention and screening
might lead to a new paradigm for cancer control. Various aspects include testing for high …

Purpose: The uptake of risk-reducing surgery in women at increased risk of breast and
ovarian cancer is highly variable between countries and centers within countries. We have …

Background To understand the dynamics that limit use of risk-management options by
women at high risk of breast cancer, there is a critical need for research that focuses on …

The prevalence of BRCA1 and BRCA2 mutations among breast cancer patients in Peru has
not yet been explored. We enrolled 266 women with breast cancer from a National cancer …

Inherited mutations in BRCA1 or BRCA2 (BRCA1/2) confer very high risk of breast and
ovarian cancers. Genetic testing and counseling can reduce risk and death from these …