The blood–brain barrier: structure, regulation, and drug delivery

D Wu, Q Chen, X Chen, F Han, Z Chen… - Signal Transduction and …, 2023 - nature.com
Blood–brain barrier (BBB) is a natural protective membrane that prevents central nervous
system (CNS) from toxins and pathogens in blood. However, the presence of BBB …

Mucosa-interfacing electronics

K Nan, VR Feig, B Ying, JG Howarth, Z Kang… - Nature Reviews …, 2022 - nature.com
The surface mucosa that lines many of our organs houses myriad biometric signals and,
therefore, has great potential as a sensor–tissue interface for high-fidelity and long-term …

Bioactive NIR-II gold clusters for three-dimensional imaging and acute inflammation inhibition

H Ma, X Zhang, L Liu, Y Huang, S Sun, K Chen… - Science …, 2023 - science.org
Strong fluorescence and high catalytic activities cannot be achieved simultaneously due to
conflicts in free electron utilization, resulting in a lack of bioactivity of most near-infrared-II …

J‐Aggregation Strategy toward Potentiated NIR‐II Fluorescence Bioimaging of Molecular Fluorophores

X Hu, C Zhu, F Sun, Z Chen, J Zou, X Chen… - Advanced …, 2024 - Wiley Online Library
Molecular fluorophores emitting in the second near‐infrared (NIR‐II, 1000–1700 nm)
window with strong optical harvesting and high quantum yields hold great potential for in …

Activatable multimodal probes for in vivo imaging and theranostics

Y Wang, Y Hu, D Ye - Angewandte Chemie, 2022 - Wiley Online Library
Multimodal imaging, which harnesses two or more imaging modalities to produce
complementary anatomical and molecular information of a living subject, has become as a …

Nanocrystals for Deep-Tissue In Vivo Luminescence Imaging in the Near-Infrared Region

Y Yang, Q Jiang, F Zhang - Chemical Reviews, 2023 - ACS Publications
In vivo imaging technologies have emerged as a powerful tool for both fundamental
research and clinical practice. In particular, luminescence imaging in the tissue-transparent …

Nanotransducer-enabled deep-brain neuromodulation with NIR-II light

X Wu, F Yang, S Cai, K Pu, G Hong - ACS nano, 2023 - ACS Publications
The second near-infrared window (NIR-II window), which ranges from 1000 to 1700 nm in
wavelength, exhibits distinctive advantages of reduced light scattering and thus deep …

Near-infrared II fluorescence imaging

EL Schmidt, Z Ou, E Ximendes, H Cui… - Nature Reviews …, 2024 - nature.com
Fluorescence imaging in the second near-infrared (NIR-II) window enables deep-tissue
imaging with high resolution and improved contrast by taking advantage of the reduced light …

Activation of mechanoluminescent nanotransducers by focused ultrasound enables light delivery to deep-seated tissue in vivo

S Jiang, X Wu, F Yang, NJ Rommelfanger, G Hong - Nature Protocols, 2023 - nature.com
Light is used extensively in biological and medical research for optogenetic
neuromodulation, fluorescence imaging, photoactivatable gene editing and light-based …

Lighting up metastasis process before formation of secondary tumor by phosphorescence imaging

K Chang, L Xiao, Y Fan, J Gu, Y Wang, J Yang… - Science …, 2023 - science.org
Metastasis is the leading cause of cancer-related deaths; until now, the detection of tumor
metastasis is mainly located at the period that secondary tumors have been formed, which …