Intratumoral heterogeneity, which is manifested in almost all of the hallmarks of cancer,
including the significantly altered metabolic profiles of cancer cells, represents a challenge …

Cancer cells are mechanically sensitive to physical properties of the microenvironment,
which can affect downstream signaling to promote malignancy, in part through the …

The development of prognostic indicators of breast cancer metastatic risk could reduce the
number of patients receiving chemotherapy for tumors with low metastatic potential. Recent …

Oxidation-reduction chemistry is fundamental to the metabolism of all living organisms, and
hence quantifying the principal redox players is important for a comprehensive …

Autofluorescence imaging (AFI) has greatly accelerated in the last decade, way past its
origins in detecting endogenous signals in biological tissues to identify differences between …

Simple Summary Gastroenteropancreatic neuroendocrine tumors (GEP-NET) account for
roughly 60% of all neuroendocrine tumors, and low/intermediate grade human GEP-NETs …

Impairments in mitochondrial energy metabolism have been implicated in human genetic
diseases associated with mitochondrial and nuclear DNA mutations, neurodegenerative and …

Tracking stem cell fate transition is crucial for understanding their development and
optimizing biomanufacturing. Destructive single-cell methods provide a pseudotemporal …

Alterations in metabolism are a hallmark of cancer. It is unclear if oxidative phosphorylation
(OXPHOS) is necessary for tumour cell survival. In this study, we investigated the effects of …

Metabolic preferences of tumor cells vary within a single tumor, contributing to tumor
heterogeneity, drug resistance, and patient relapse. However, the relationship between …