Unmet needs in preventive treatment of migraine

E Bentivegna, D Onan, P Martelletti - Neurology and Therapy, 2023 - Springer
Migraine represents the most common cause of work disability in young women and the
second one in the general population. Preventive treatment can reduce the frequency of …

Changes in migraine interictal burden following treatment with galcanezumab: Results from a phase III randomized, placebo‐controlled study

RB Lipton, DC Buse, CH Sandoe… - … : The Journal of …, 2023 - Wiley Online Library
Objective To evaluate changes in interictal burden with galcanezumab versus placebo in
patients with episodic (EM) or chronic migraine (CM). Background The disruptive effects of …

Emerging drugs for the preventive treatment of migraine: a review of CGRP monoclonal antibodies and gepants trials

M Silvestro, I Orologio, M Siciliano, F Trojsi… - Expert Opinion on …, 2023 - Taylor & Francis
Introduction Migraine is a leading cause of years lived with disability and preventive
strategies represent a mainstay to reduce health-related disability and improve quality of life …

One-year prospective real-world assessment of effectiveness and safety of erenumab in migraine prevention: results of the French FHU INOVPAIN registry study

M Lanteri-Minet, R Fabre, C Martin, K Pradat… - The Journal of …, 2023 - Springer
Background Randomized clinical trials have demonstrated efficacy and safety of erenumab.
The aim of this study is to evaluate the effectiveness and safety of erenumab in a real-world …

Efficacy and safety of eptinezumab for migraine prevention in patients with prior preventive treatment failures: subgroup analysis of the randomized, placebo …

M Ashina, M Lanteri-Minet, A Ettrup… - …, 2023 - journals.sagepub.com
Background Migraine is a disabling neurological disease adversely affecting many aspects
of life. Most patients are still required to have failed several older oral preventive therapies …

Pharmacologic prevention of migraine

V Tzankova, WJ Becker, TLH Chan - Cmaj, 2023 - Can Med Assoc
• Oral medications traditionally used for the prevention of migraine and known to be effective
include anti-epileptic, β-blocker, antihypertensive and antidepressant drugs.• …

Long-term effectiveness and tolerability of galcanezumab in patients with migraine excluded from clinical trials: real world evidence of 1055 patients with 1 year follow …

V Obach, F Velasco, R Alvarez Escudero… - The Journal of …, 2023 - Springer
Background Galcanezumab has shown efficacy and effectiveness in the treatment of
episodic and chronic migraine (CM), however, the population represented in randomized …

Adverse event reporting of four anti-Calcitonin gene-related peptide monoclonal antibodies for migraine prevention: a real-world study based on the FDA adverse …

W Sun, Y Li, B Xia, J Chen, Y Liu, J Pang… - Frontiers in …, 2024 - frontiersin.org
Background: Anti-Calcitonin gene-related peptide monoclonal antibodies (anti-CGRP mAbs)
have shown significant efficacy in preventing migraine. However, there have been limited …

Real-world experience with calcitonin gene-related peptide-targeted antibodies for migraine prevention: a retrospective observational cohort study at two Japanese …

M Shibata, K Fujita, E Hoshino, K Minami, K Koizumi… - BMC neurology, 2024 - Springer
Background Although randomized controlled trials (RCTs) have shown that calcitonin gene-
related peptide (CGRP)-targeted monoclonal antibodies (CGRP mAbs) are an efficacious …

Long-term effectiveness of eptinezumab in patients with migraine and prior preventive treatment failures: extension of a randomized controlled trial

M Ashina, SJ Tepper, A Gendolla, B Sperling… - The Journal of …, 2023 - Springer
Background Eptinezumab demonstrated efficacy in adults with migraine and prior preventive
treatment failures in the placebo-controlled phase of the DELIVER clinical trial; its long-term …