[HTML][HTML] A global perspective on the convergence of hypervirulence and carbapenem resistance in Klebsiella pneumoniae

P Lan, Y Jiang, J Zhou, Y Yu - Journal of global antimicrobial resistance, 2021 - Elsevier
Hypervirulence and carbapenem resistance have emerged as two distinct evolutionary
directions for Klebsiella pneumoniae, which pose a great threat in clinical settings. Multiple …

[HTML][HTML] Virulence evolution, molecular mechanisms of resistance and prevalence of ST11 carbapenem-resistant Klebsiella pneumoniae in China: a review over the …

W Liao, Y Liu, W Zhang - Journal of global antimicrobial resistance, 2020 - Elsevier
ST11 carbapenem-resistant K. pneumoniae (CRKP) has been the dominant clone in China.
In this review, we trace the prevalence of ST11 CRKP in China Antimicrobial Surveillance …

Clinical outcomes and bacterial characteristics of carbapenem-resistant Klebsiella pneumoniae complex among patients from different global regions (CRACKLE-2): a …

M Wang, M Earley, L Chen, BM Hanson… - The Lancet Infectious …, 2022 - thelancet.com
Summary Background Carbapenem-resistant Klebsiella pneumoniae (CRKP) is a global
threat. We therefore analysed the bacterial characteristics of CRKP infections and the …

Epidemiological characteristics and molecular evolution mechanisms of carbapenem-resistant hypervirulent Klebsiella pneumoniae

YL Han, XH Wen, W Zhao, XS Cao, JX Wen… - Frontiers in …, 2022 - frontiersin.org
Carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKP), a type of Klebsiella
pneumoniae (KP) that exhibits hypervirulence and carbapenem resistance phenotypes, can …

A point mutation in recC associated with subclonal replacement of carbapenem-resistant Klebsiella pneumoniae ST11 in China

K Zhou, CX Xue, T Xu, P Shen, S Wei, KL Wyres… - Nature …, 2023 - nature.com
Adaptation to selective pressures is crucial for clinically important pathogens to establish
epidemics, but the underlying evolutionary drivers remain poorly understood. The current …

Characterization of phage resistance and phages capable of intestinal decolonization of carbapenem-resistant Klebsiella pneumoniae in mice

Q Fang, Y Feng, A McNally, Z Zong - Communications Biology, 2022 - nature.com
Carbapenem-resistant Klebsiella pneumoniae (CRKP) has emerged as a severe global
health challenge. We isolate and characterize two previously unidentified lytic phages, P24 …

Global spread and evolutionary convergence of multidrug-resistant and hypervirulent Klebsiella pneumoniae high-risk clones

G Arcari, A Carattoli - Pathogens and Global Health, 2023 - Taylor & Francis
For people living in developed countries life span is growing at a faster pace than ever. One
of the main reasons for such success is attributable to the introduction and extensive use in …

[HTML][HTML] “Superbugs” with hypervirulence and carbapenem resistance in Klebsiella pneumoniae: the rise of such emerging nosocomial pathogens in China

D Pu, J Zhao, K Chang, X Zhuo, B Cao - Science Bulletin, 2023 - Elsevier
Although hypervirulent Klebsiella pneumoniae (hvKP) can produce community-acquired
infections that are fatal in young and adult hosts, such as pyogenic liver abscess …

Resistance evolution of hypervirulent carbapenem-resistant Klebsiella pneumoniae ST11 during treatment with tigecycline and polymyxin

X Jin, Q Chen, F Shen, Y Jiang, X Wu… - Emerging microbes & …, 2021 - Taylor & Francis
Hypervirulent carbapenem-resistant Klebsiella pneumoniae (hv-CRKP) has recently
aroused increasing attention, especially ST11, the predominant CRKP clone in China. Here …

Anatomy of an extensively drug-resistant Klebsiella pneumoniae outbreak in Tuscany, Italy

MJ Martin, BW Corey, F Sannio… - Proceedings of the …, 2021 - National Acad Sciences
A protracted outbreak of New Delhi metallo-β-lactamase (NDM)–producing carbapenem-
resistant Klebsiella pneumoniae started in Tuscany, Italy, in November 2018 and continued …