Drug resistance in epilepsy

E Perucca, P Perucca, HS White, EC Wirrell - The Lancet Neurology, 2023 - thelancet.com
Drug resistance is estimated to affect about a third of individuals with epilepsy, but its
prevalence differs in relation to the epilepsy syndrome, the cause of epilepsy, and other …

[HTML][HTML] Neuroinflammation microenvironment sharpens seizure circuit

B Villasana-Salazar, A Vezzani - Neurobiology of Disease, 2023 - Elsevier
A large set of inflammatory molecules and their receptors are induced in epileptogenic foci
of patients with pharmacoresistant epilepsies of structural etiologies or with refractory status …

International consensus recommendations for management of new onset refractory status epilepticus including febrile infection‐related epilepsy syndrome …

R Wickstrom, O Taraschenko, R Dilena, ET Payne… - …, 2022 - Wiley Online Library
Objective This study was undertaken to develop consensus‐based recommendations for the
management of adult and pediatric patients with new onset refractory status epilepticus …

[HTML][HTML] Strategies for precision vagus neuromodulation

U Ahmed, YC Chang, S Zafeiropoulos… - Bioelectronic …, 2022 - Springer
The vagus nerve is involved in the autonomic regulation of physiological homeostasis,
through vast innervation of cervical, thoracic and abdominal visceral organs. Stimulation of …

[HTML][HTML] Role of neuroinflammation and blood-brain barrier permutability on migraine

G Yamanaka, S Suzuki, N Morishita… - International journal of …, 2021 - mdpi.com
Currently, migraine is treated mainly by targeting calcitonin gene-related peptides, although
the efficacy of this method is limited and new treatment strategies are desired …

[HTML][HTML] The putative role of neuroinflammation in the complex pathophysiology of migraine: from bench to bedside

L Biscetti, E Cresta, LM Cupini, P Calabresi… - Neurobiology of …, 2023 - Elsevier
The implications of neurogenic inflammation and neuroinflammation in the pathophysiology
of migraine have been clearly demonstrated in preclinical migraine models involving several …

[HTML][HTML] Microglia in epilepsy

C Yu, X Deng, D Xu - Neurobiology of Disease, 2023 - Elsevier
Epilepsy is one of most common chronic neurological disorders, and the antiseizure
medications developed by targeting neurocentric mechanisms have not effectively reduced …

[HTML][HTML] Molecular mechanisms in the genesis of seizures and epilepsy associated with viral infection

W Löscher, CL Howe - Frontiers in molecular neuroscience, 2022 - frontiersin.org
Seizures are a common presenting symptom during viral infections of the central nervous
system (CNS) and can occur during the initial phase of infection (“early” or acute …

[HTML][HTML] Neuroinflammation: the pathogenic mechanism of neurological disorders

A Gorji - International Journal of Molecular Sciences, 2022 - mdpi.com
Neuroinflammation is implicated in the pathophysiology of several neurological diseases.
The key role of neuroinflammation in a wide range of neurological disorders makes it highly …

[HTML][HTML] Experimental and clinical investigation of cytokines in migraine: a narrative review

G Yamanaka, K Hayashi, N Morishita… - International Journal of …, 2023 - mdpi.com
The role of neuroinflammation in the pathophysiology of migraines is increasingly being
recognized, and cytokines, which are important endogenous substances involved in …