2012 ACCF/AHA/ACP/AATS/PCNA/SCAI/STS guideline for the diagnosis and management of patients with stable ischemic heart disease: a report of the American …

SD Fihn, JM Gardin, J Abrams, K Berra… - Journal of the American …, 2012 - jacc.org
The recommendations listed in this document are, whenever possible, evidence based. An
extensive evidence review was conducted as the document was compiled through …

Oral antiplatelet therapy after acute coronary syndrome: a review

H Kamran, H Jneid, WT Kayani, SS Virani, GN Levine… - Jama, 2021 - jamanetwork.com
Importance Acute coronary syndrome (ACS) is a major cause of morbidity and mortality in
the United States with an annual incidence of approximately 1 million. Dual antiplatelet …

The Safety and Efficacy of Aspirin Discontinuation on a Background of a P2Y12 Inhibitor in Patients After Percutaneous Coronary Intervention: A Systematic Review …

ML O'Donoghue, SA Murphy, MS Sabatine - Circulation, 2020 - Am Heart Assoc
Background: Dual antiplatelet therapy with aspirin and a P2Y12 inhibitor has been shown to
reduce the risk of major adverse cardiovascular events (MACE) compared with aspirin alone …

Clinical Pharmacogenetics Implementation Consortium Guidelines for CYP2C19 Genotype and Clopidogrel Therapy: 2013 Update

SA Scott, K Sangkuhl, CM Stein… - Clinical …, 2013 - Wiley Online Library
Cytochrome P450 (CYP) 2C19 catalyzes the bioactivation of the antiplatelet prodrug
clopidogrel, and CYP2C19 loss‐of‐function alleles impair formation of active metabolites …

AHA/ACCF secondary prevention and risk reduction therapy for patients with coronary and other atherosclerotic vascular disease: 2011 update: a guideline from the …

SC Smith Jr, EJ Benjamin, RO Bonow, LT Braun… - Circulation, 2011 - Am Heart Assoc
(ACCF) guidelines on secondary prevention, 1 important evidence from clinical trials has
emerged that further supports and broadens the merits of intensive risk-reduction therapies …

Association between CYP2C19 loss-of-function allele status and efficacy of clopidogrel for risk reduction among patients with minor stroke or transient ischemic attack

Y Wang, X Zhao, J Lin, H Li, SC Johnston, Y Lin, Y Pan… - Jama, 2016 - jamanetwork.com
Importance Data are limited regarding the association betweenCYP2C19genetic variants
and clinical outcomes of patients with minor stroke or transient ischemic attack treated with …

Effect of CYP2C19 Genotype on Ischemic Outcomes During Oral P2Y12 Inhibitor Therapy: A Meta-Analysis

NL Pereira, C Rihal, R Lennon, G Marcus… - Cardiovascular …, 2021 - jacc.org
Objectives The aim of this study was to examine the effect of CYP2C19 genotype on clinical
outcomes in patients with coronary artery disease (CAD) who predominantly underwent …

[HTML][HTML] A tale of coronary artery disease and myocardial infarction

EG Nabel, E Braunwald - New England Journal of Medicine, 2012 - Mass Medical Soc
A Tale of Coronary Artery Disease and Myocardial Infarction | NEJM Skip to main content NEJM
Group Follow Us Facebook Twitter Instagram YouTube LinkedIn Prepare to become a …

2012 ACCF/AHA focused update incorporated into the ACCF/AHA 2007 guidelines for the management of patients with unstable angina/non–ST-elevation myocardial …

2007 Writing Committee Members, JL Anderson… - Circulation, 2013 - Am Heart Assoc
It is important that the medical profession play a significant role in critically evaluating the
use of diagnostic procedures and therapies as they are introduced and tested in the …

Guidelines for the primary prevention of stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association

LB Goldstein, CD Bushnell, RJ Adams, LJ Appel… - Stroke, 2011 - Am Heart Assoc
Background and Purpose—This guideline provides an overview of the evidence on
established and emerging risk factors for stroke to provide evidence-based …