Intense investigation continues on the pathobiology of stent thrombosis (ST) because of its
morbidity and mortality. Because little advance has been made in outcomes following ST …

Background Drug interactions can have desired, reduced or unwanted effects. The
probability of interactions increases with the number of drugs taken. The high rate of …

Despite the recent advances in medical science, the folk wisdom of" prevention is better than
cure" remains unequivocally true for stroke and other cerebrovascular disease. In this issue …

Antiplatelet therapy has been successful in reducing mortality and morbidity in acute
myocardial infarction. Recent advances in understanding the molecular basis of the role of …

Proton pump inhibitors have an excellent safety profile and have become one of the most
commonly prescribed class of drugs in primary and specialty care. Long-term, sometimes …

Since its introduction in 1977, percutaneous coronary intervention has become one of the
most commonly performed therapeutic procedures worldwide. Such widespread diffusion …

Objectives: The aim of this study was to assess the association between the loss-of-function
cytochrome P450 2C19 (CYP2C19)* 2 variant (10 studies, 11,959 patients) or the use of …

During the last 10-15 years, cytochrome P450 (CYP) 2C8 has emerged as an important drug-
metabolizing enzyme. CYP2C8 is highly expressed in human liver and is known to …

Ticlopidine, clopidogrel, and prasugrel are thienopyridine prodrugs that inhibit adenosine‐
5′‐diphosphate (ADP)‐mediated platelet aggregation in vivo. These compounds are …

Introduction: Variability of drug response is an important consideration in clinical medicine. A
major determinant of drug response variability is hepatic cytochrome P450 oxidase …