The discovery of the medicinal properties of gold complexes has fuelled the design and
synthesis of new anticancer metallodrugs, which have received special attention due to their …

G-quadruplexes (G4s) are noncanonical nucleic acid structures involved in the regulation of
key cellular processes, such as transcription and replication. Since their discovery, G4s have …

Nucleic acid sequences able to adopt a G-quadruplex conformation are overrepresented
within the human genome. This evidence strongly suggests that these genomic regions …

Cancer is a societal burden demanding innovative approaches. A major problem with the
conventional chemotherapeutic agents is their strong toxicity and other side effects due to …

TERRA is a class of telomeric repeat-containing RNAs that are expressed from telomeres in
multiple organisms. TERRA transcripts play key roles in telomere maintenance and their …

In recent years, the accelerated development of G-quadruplexes and hydrogels has driven
the development of intelligent biomaterials. Based on the excellent biocompatibility and …

Palmatine (PLT) is a natural isoquinoline alkaloid that belongs to the class of
protoberberines and exhibits a wide spectrum of pharmacological and biological properties …

Nucleic-acid aptamers consisting in single-stranded DNA oligonucleotides emerged as very
promising biorecognition elements for electrochemical biosensors applied in various fields …

The formation of G-quadruplex structures (G4s) in vitro from guanine (G)-rich nucleic acid
sequences of DNA and RNA stabilized with monovalent cations, typically K+ and Na+, under …

DNA has the ability to form polymorphic structures like canonical duplex DNA and non-
canonical triplex DNA, Cruciform, Z-DNA, G-quadruplex (G4), i-motifs, and hairpin structures …