Haemostasis stops bleeding at the site of vascular injury and maintains the integrity of blood
vessels through clot formation. This regulated physiological process consists of complex …

Platelets, non-nucleated blood components first described over 130 years ago, are
recognized as the primary cell regulating hemostasis and thrombosis. The vascular …

The immune system is a very diverse system of the host that evolved during evolution to
cope with various pathogens present in the vicinity of environmental surroundings inhabited …

NETosis is a regulated form of neutrophil cell death that contributes to the host defense
against pathogens and was linked to various diseases soon after its first description in 2004 …

Beyond their important role in hemostasis, platelets play a crucial role in inflammatory
diseases. This becomes apparent during sepsis, where platelet count and activation …

Platelets are anucleate cells produced by megakaryocytes. In recent years, a robust body of
literature supports the evolving role of platelets as key sentinel and effector cells in infectious …

Sepsis is a complex syndrome with a high incidence, increasing by 8.7% annually over the
last 20 years. Coagulopathy is a leading factor associated with mortality in patients with …

The development of cell membrane-modified biomimetic nanoparticles has extensively
increased during the past years due to their exceptional biocompatibility, evasion from the …

Significant cross talk occurs between inflammation and coagulation. Thus, coagulopathy is
common in sepsis, potentially aggravating the prognosis. Initially, septic patients tend to …

Host defense against infection is based on two crucial mechanisms: the inflammatory
response and the activation of coagulation. Platelets are involved in both hemostasis and …