Abstract Since the Great Oxidation Event, about 2.4 billion years ago, the Earth is immersed
in an oxidizing atmosphere. Thus, it has been proposed that excess oxygen, originally a …

This article looks back to the antioxidant/free radical field in 1994 and discusses how it has
progressed in the past 18 years. In some areas, there has been little change: the role of …

Sirtuin 1 (SIRT1) regulates inflammation, aging (life span and health span), calorie
restriction/energetics, mitochondrial biogenesis, stress resistance, cellular senescence …

The term 'antioxidant paradox'is often used to refer to the observation that oxygen radicals
and other reactive oxygen species are involved in several human diseases, but giving large …

Heme oxygenases are composed of two isozymes, Hmox1 and Hmox2, that catalyze the
degradation of heme to carbon monoxide (CO), ferrous iron, and biliverdin, the latter of …

AMPK (AMP-activated protein kinase) is one of the key players in maintaining intracellular
homoeostasis. AMPK is well known as an energy sensor and can be activated by increased …

My interest in biological chemistry proceeded from enzymology in vitro to the study of
physiological chemistry in vivo. Investigating biological redox reactions, I identified hydrogen …

The peroxisome proliferator-activated receptors (PPAR) belong to the nuclear superfamily of
ligand-activated transcription factors. PPARγ acts as a nutrient sensor that regulates several …

Background Diabetic patients experience accelerated atherosclerosis. Metformin is a
cornerstone of the current therapy of type 2 diabetes. Macrophages are the key cells …

Plants of the species Fridericia chica (Bonpl.) LG Lohmann (Bignoniaceae), which are
widely distributed in Brazil and named crajiru in the state of Amazonas, are known in folk …