Dopamine, immunity, and disease

B Channer, SM Matt, EA Nickoloff-Bybel, V Pappa… - Pharmacological …, 2023 - ASPET
The neurotransmitter dopamine is a key factor in central nervous system (CNS) function,
regulating many processes including reward, movement, and cognition. Dopamine also …

Endogenous photosensitizers in human skin

EL Bastos, FH Quina, MS Baptista - Chemical Reviews, 2023 - ACS Publications
Endogenous photosensitizers play a critical role in both beneficial and harmful light-induced
transformations in biological systems. Understanding their mode of action is essential for …

[HTML][HTML] Janus kinase inhibitors in the treatment of vitiligo: a review

F Qi, F Liu, L Gao - Frontiers in immunology, 2021 - frontiersin.org
Vitiligo is a multifactorial reversible skin disorder characterized by distinct white patches that
result from melanocyte destruction. Activated CXCR3+ CD8+ T cells promote melanocyte …

Promising natural products in new drug design, development, and therapy for skin disorders: An overview of scientific evidence and understanding their mechanism of …

NA Mohd Zaid, M Sekar, SR Bonam… - Drug design …, 2023 - Taylor & Francis
The skin is the largest organ in the human body, composed of the epidermis and the dermis.
It provides protection and acts as a barrier against external menaces like allergens …

Guidelines of care for the management of atopic dermatitis: section 2. Management and treatment of atopic dermatitis with topical therapies

LF Eichenfield, WL Tom, TG Berger, A Krol… - Journal of the American …, 2014 - Elsevier
Atopic dermatitis is a common and chronic, pruritic inflammatory skin condition that can
affect all age groups. This evidence-based guideline addresses important clinical questions …

Prevalence of vitiligo among adults in the United States

K Gandhi, K Ezzedine, KP Anastassopoulos… - JAMA …, 2022 - jamanetwork.com
Importance Vitiligo can have profound effects on patients and is often associated with other
autoimmune comorbid conditions. It is important to understand the current prevalence of …

[HTML][HTML] The role of oxidative stress in vitiligo: an update on its pathogenesis and therapeutic implications

WL Chang, CH Ko - Cells, 2023 - mdpi.com
Vitiligo is an autoimmune skin disorder caused by dysfunctional pigment-producing
melanocytes which are attacked by immune cells. Oxidative stress is considered to play a …

[HTML][HTML] Vitiligo, from pathogenesis to therapeutic advances: state of the art

F Diotallevi, H Gioacchini, E De Simoni… - International Journal of …, 2023 - mdpi.com
Vitiligo is an acquired hypopigmentation of the skin due to a progressive selective loss of
melanocytes; it has a prevalence of 1–2% and appears as rounded, well-demarcated white …

[HTML][HTML] How does vitamin D affect immune cells crosstalk in autoimmune diseases?

D Gallo, D Baci, N Kustrimovic, N Lanzo… - International Journal of …, 2023 - mdpi.com
Vitamin D is a secosteroid hormone that is highly involved in bone health. Mounting
evidence revealed that, in addition to the regulation of mineral metabolism, vitamin D is …

[HTML][HTML] Efficacy and safety of oral ritlecitinib for the treatment of active nonsegmental vitiligo: a randomized phase 2b clinical trial

K Ezzedine, E Peeva, Y Yamaguchi, LA Cox… - Journal of the American …, 2023 - Elsevier
Background Vitiligo is a chronic autoimmune disorder characterized by depigmented
patches of the skin. Objective To evaluate the efficacy and safety of ritlecitinib, an oral JAK3 …