Octopamine (OA) and tyramine (TA) are closely related biogenic monoamines that act as
signalling compounds in invertebrates, where they fulfil the roles played by adrenaline and …

The model organism Drosophila melanogaster was increasingly applied in nutrition
research in recent years. A range of methods are available for the phenotyping of D …

Sleep is a highly conserved state, suggesting that sleep's benefits outweigh the increased
vulnerability it brings. Yet, little is known about how sleep fulfills its functions. Here, we used …

High-sugar diets cause thirst, obesity, and metabolic dysregulation, leading to diseases
including type 2 diabetes and shortened lifespan. However, the impact of obesity and water …

Hunger is an ancient drive, yet the molecular nature of pressures of this sort and how they
modulate physiology are unknown. We find that hunger modulates aging in Drosophila …

In patients with advanced-stage cancer, cancer-associated anorexia affects treatment
success and patient survival. However, the underlying mechanism is poorly understood …

Adipose tissue is essential for whole-body glucose homeostasis, with a primary role in lipid
storage. It has been previously observed that lactate production is also an important …

The effects of aging on the brain are widespread and can have dramatic implications on the
overall health of an organism. Mitochondrial dysfunction is a hallmark of brain aging, but the …

Protein translation (PT) declines with age in invertebrates, rodents, and humans. It has been
assumed that elevated PT at young ages is beneficial to health and PT ends up dropping as …

Prolonged exposure to food dyes, even for those considered safe for consumption, are
known to have toxic effects. However, we lack a proper understanding of the underlying …