Tuberculosis treatment monitoring and outcome measures: new interest and new strategies

J Heyckendorf, SB Georghiou, N Frahm… - Clinical microbiology …, 2022 - Am Soc Microbiol
Despite the advent of new diagnostics, drugs and regimens, tuberculosis (TB) remains a
global public health threat. A significant challenge for TB control efforts has been the …

Reimagining the status quo: How close are we to rapid sputum-free tuberculosis diagnostics for all?

RR Nathavitharana, AL Garcia-Basteiro, M Ruhwald… - …, 2022 - thelancet.com
Rapid, accurate, sputum-free tests for tuberculosis (TB) triage and confirmation are urgently
needed to close the widening diagnostic gap. We summarise key technologies and review …

Immune biomarkers for diagnosis and treatment monitoring of tuberculosis: current developments and future prospects

YK Yong, HY Tan, A Saeidi, WF Wong… - Frontiers in …, 2019 - frontiersin.org
Tuberculosis (TB) treatment monitoring is paramount to clinical decision-making and the
host biomarkers appears to play a significant role. The currently available diagnostic …

Tuberculosis phenotypic and genotypic drug susceptibility testing and immunodiagnostics: a review

KA Yusoof, JI García, A Schami… - Frontiers in …, 2022 - frontiersin.org
Tuberculosis (TB), considered an ancient disease, is still killing one person every 21
seconds. Diagnosis of Mycobacterium tuberculosis (M. tb) still has many challenges …

HLA-DR marks recently divided antigen-specific effector CD4 T cells in active tuberculosis patients

R Tippalagama, A Singhania, P Dubelko… - The Journal of …, 2021 - journals.aai.org
Upon Ag encounter, T cells can rapidly divide and form an effector population, which plays
an important role in fighting acute infections. In humans, little is known about the molecular …

[HTML][HTML] Diagnosis and biomarkers for ocular tuberculosis: From the present into the future

Z Ludi, AA Sule, RP Samy, I Putera, B Schrijver… - Theranostics, 2023 - ncbi.nlm.nih.gov
Tuberculosis is an airborne disease caused by Mycobacterium tuberculosis (Mtb) and can
manifest both pulmonary and extrapulmonary disease, including ocular tuberculosis (OTB) …

Classical CD4 T cells as the cornerstone of antimycobacterial immunity

J Morgan, K Muskat, R Tippalagama… - Immunological …, 2021 - Wiley Online Library
Tuberculosis is a significant health problem without an effective vaccine to combat it. A
thorough understanding of the immune response and correlates of protection is needed to …

Perspective for precision medicine for tuberculosis

C Lange, R Aarnoutse, D Chesov… - Frontiers in …, 2020 - frontiersin.org
Tuberculosis is a bacterial infectious disease that is mainly transmitted from human to
human via infectious aerosols. Currently, tuberculosis is the leading cause of death by an …

Disease extent and anti‐tubercular treatment response correlates with Mycobacterium tuberculosis‐specific CD4 T‐cell phenotype regardless of HIV‐1 status

C Riou, E Du Bruyn, S Ruzive… - Clinical & …, 2020 - Wiley Online Library
Objectives The development of non‐sputum‐based assays for tuberculosis (TB) diagnosis
and treatment monitoring is a key priority. Recent data indicate that whole blood‐based …

CD38+CD27TNF-α + on Mtb-specific CD4+ T Cells Is a Robust Biomarker for Tuberculosis Diagnosis

MP Acharya, SP Pradeep, VS Murthy… - Clinical Infectious …, 2021 - academic.oup.com
Background Early and accurate diagnosis followed by timely treatment are the key
prerequisites to fight tuberculosis (TB) and reduce its global burden. Despite scientific …