The activation and transdifferentiation of hepatic stellate cells (HSCs) into contractile, matrix-
producing myofibroblasts (MFBs) are central events in hepatic fibrogenesis. These …

Regardless of the cause, symptomatic heart failure (HF) with reduced ejection fraction (rEF)
is characterized by pathological activation of the renin–angiotensin–aldosterone system …

Left ventricular hypertrophy and fibrosis are major risk factors for heart failure, which require
timely and effective treatment. Genetic therapy has been shown to ameliorate hypertrophic …

Properly balanced cellular responses require both the mutual interactions of soluble factors
with cell surface receptors and the crosstalk of intracellular molecules. In particular, immune …

Soluble M6P/IGFIIR has the potential to be a significant carrier of IGF-II and mannose 6-P
proteins in the circulation and play an important role as an antagonist to the cellular …

For more than 130 years, the hepatic stellate cells (also known as Ito cells) have been the
object of numerous studies that aimed at their characterization both in normal and …

Objectives To look at the possible effect of IGF2R rs9456497 on cardiovascular risks in a
long-lived population. Methods IGF-2R rs9456497 was genotyped by iMLDR for 496 long …

Cardiac hypertrophy in its pure sense describes the ability of cardiomyocytes to increase
their cell shape in the absence of cell proliferation. As the large majority of mammalian …

Einleitung: Die moykardiale Hypertrophie spielt eine wichtige Rolle in der Pathophysiolgie
der Herzinsuffizienz. Dieser (mal) adaptive Mechanismus führt letztlich zum nekrotischen …

La obesidad se ha convertido en las últimas décadas en una de las principales causas de
muerte y discapacidad, pasando a considerarse un grave problema de salud pública …