Background: Recent oral contraceptive use has been associated with a small increase in
breast cancer risk and a substantial decrease in ovarian cancer risk. The effects on risks for …

Objective Subjects with germline BRCA1/2 mutations (g BRCA m) have an increased risk of
developing ovarian cancer and enhanced sensitivity to platinum-containing agents and …

The authors propose a novel approach to evaluate the effects of risk factors on disease risks
in carriers of high‐penetrance alleles in disease susceptibility genes. Most studies to date …

Women with mutations in BRCA1 or BRCA2 are at tremendously increased lifetime risk of
both breast and BRCA-associated gynecologic (ovarian, fallopian tube, and primary …

Ovarian cancer is the most lethal of the gynecologic malignancies. Because ovarian cancer
symptoms are subtle and nonspecific, the diagnosis is often delayed until the disease is well …

Background: Understanding the effect of oral contraceptives on risk of breast cancer in
BRCA1 or BRCA2 mutation carriers is important because oral contraceptive use is a …

During the period of this review, the importance of several known risk factors was confirmed,
whereas the effects of other factors became more clear. Chemoprevention and prophylactic …

In the general population, ovarian cancer risk is inversely associated with oral contraceptive
use, tubal ligation, and childbearing. Among carriers of BRCA1 gene mutations, the data are …

Ethnic differences in cancer incidence and mortality result from differences in genetic and
epidemiologic risk factors. Mutations in BRCA1 and BRCA2 account for a small proportion of …

763 ovarian cancer risk, most dietary factors are unlikely to play a major role in ovarian
cancer development. Coffee has not been consistently associated with ovarian cancer. A …