Microorganisms, including bacteria, viruses, fungi, and other eukaryotes, play critical roles in
human health. An altered microbiome can be associated with complex diseases …

Simple Summary Despite recent therapeutic advances against cancer, many patients do not
respond well or respond poorly, to treatment and develop resistance to more than one anti …

The tumor microenvironment (TME) influences tumor growth, metastatic spread and
response to treatment. Often immunosuppression, mediated by the TME, impairs a beneficial …

Simple Summary Cancer is one of the most debated problems all over the world. Cancer
stem cells are considered responsible of tumor initiation, metastasis, drug resistance, and …

The tumor microenvironment (TME) is a major contributor to cancer malignancy including
development of therapeutic resistance, a process mediated in part through intercellular …

Background The incidence and mortality of gastric cancer ranks fifth and fourth worldwide
among all malignancies, respectively. Accumulating evidences have revealed the close …

Tumor microenvironment (TME), which is characterized by hypoxia, widely exists in solid
tumors. As a current research hotspot in the TME, hypoxia is expected to become a key …

Cellular and stromal components including tumor cells, immune cells, mesenchymal cells,
cancer-linked fibroblasts, and extracellular matrix, constituent tumor microenvironment …

Malignant tumors represent a major threat to global health and the search for effective
treatments is imperative. While various treatments exist, including surgery, radiotherapy …

Colorectal cancer is considered one of the major malignancies that threaten the lives and
health of people around the world. Patients with CRC are prone to post-operative local …