Weight loss and food intake disturbances that often precede cognitive decline and diagnosis
have been extensively reported in Alzheimer's disease patients. Previously, we observed …

Alzheimer's disease (AD) patients suffer sleep disorders and circadian rhythm disturbances
(CRDs). The underlying mechanisms are incompletely understood, and treatments are …

Alzheimer's disease (AD) is characterized by age-dependent biochemical, metabolic, and
physiologic changes. These age-dependent changes ultimately converge to impair cognitive …

Obesity and cognitive decline can occur in association. Brain dysmetabolism and insulin
resistance might be common underlying traits. We aimed to examine the effect of high-fat …

Alzheimer's disease (AD) is associated with disrupted circadian rhythms and sleep, which
are thought to reflect an impairment of internal circadian timekeeping that contribute to …

Circadian dysfunction has been described in patients with symptomatic Alzheimer's disease
(AD), as well as in presymptomatic phases of the disease. Modeling this circadian …

Alzheimer's disease (AD), the most common dementia in the elderly, is characterized by
cognitive impairment and severe autonomic symptoms such as disturbance in core body …

Here, we show the role of melatonin combined with or without exercise as a determinant of
multicellular behavior in osteoarthritis. We address the relationship between the molecular …

Alzheimer's disease (AD) is characterized by neuronal loss and accumulation of β-amyloid-
protein (Aβ) in the brain parenchyma. Sleep impairment is associated with AD and affects …

Despite advances in understanding the pathophysiology of Alzheimer's disease (AD), its
therapy remains largely symptomatic and supportive. Acetylcholinesterase inhibitors-the first …