Mechanisms of central hypogonadism

TM Barber, I Kyrou, G Kaltsas, AB Grossman… - International Journal of …, 2021 - mdpi.com
Reproductive function depends upon an operational hypothalamo–pituitary–gonadal (HPG)
axis. Due to its role in determining survival versus reproductive strategies, the HPG axis is …

Endocrine dysfunction after traumatic brain injury: an ignored clinical syndrome?

C Mahajan, H Prabhakar, F Bilotta - Neurocritical care, 2023 - Springer
Traumatic brain injury (TBI) incurs substantial health and economic burden, as it is the
leading reason for death and disability globally. Endocrine abnormalities are no longer …

Isolated anterior pituitary dysfunction in adulthood

N Prencipe, L Marinelli, E Varaldo, D Cuboni… - Frontiers in …, 2023 - frontiersin.org
Hypopituitarism is defined as a complete or partial deficiency in one or more pituitary
hormones. Anterior hypopituitarism includes secondary adrenal insufficiency, central …

Traumatic brain injury as frequent cause of hypopituitarism and growth hormone deficiency: epidemiology, diagnosis, and treatment

V Gasco, V Cambria, F Bioletto, E Ghigo… - Frontiers in …, 2021 - frontiersin.org
Traumatic brain injury (TBI)-related hypopituitarism has been recognized as a clinical entity
for more than a century, with the first case being reported in 1918. However, during the 20th …

Neuroinflammation and hypothalamo-pituitary dysfunction: focus of traumatic brain injury

C Mele, V Pingue, M Caputo, M Zavattaro… - International journal of …, 2021 - mdpi.com
The incidence of traumatic brain injury (TBI) has increased over the last years with an
important impact on public health. Many preclinical and clinical studies identified multiple …

Functional overlay model of persistent post-concussion syndrome

I Mavroudis, S Chatzikonstantinou, F Petridis… - Brain Sciences, 2023 - mdpi.com
Persistent post-concussion syndrome (PPCS) is a complex and debilitating condition that
can develop after head concussions or mild traumatic brain injury (mTBI). PPCS is …

Plasma phosphorylated tau181 as a biomarker of mild traumatic brain injury: findings from THINC and NCAA-DoD CARE Consortium prospective cohorts

C Devoto, R Vorn, S Mithani, TB Meier, C Lai… - Frontiers in …, 2023 - frontiersin.org
Objective The aim of this study was to investigate phosphorylated tau (p-tau181) protein in
plasma in a cohort of mild traumatic brain injury (mTBI) patients and a cohort of concussed …

Growth hormone deficiency following traumatic brain injury in pediatric and adolescent patients: presentation, treatment, and challenges of transitioning from pediatric …

TL Wexler, K Reifschneider, P Backeljauw… - Journal of …, 2023 - liebertpub.com
Traumatic brain injury (TBI) is increasingly recognized, with an incidence of approximately
110 per 100,000 in pediatric populations and 618 per 100,000 in adolescent and adult …

Neurobiology of puberty and its disorders

SF Witchel, TM Plant - Handbook of Clinical Neurology, 2021 - Elsevier
Puberty, which in humans is considered to include both gonadarche and adrenarche, is the
period of becoming capable of reproducing sexually and is recognized by maturation of the …

[HTML][HTML] A consensus on optimization of care in patients with growth hormone deficiency and mild traumatic brain injury

KCJ Yuen, B Masel, MS Jaffee, G O'Shanick… - Growth Hormone & IGF …, 2022 - Elsevier
Abstract Objective/design Approximately 2.9 million children and adults in the US
experience traumatic brain injuries (TBIs) annually, most of which are considered mild. TBI …