Molecular pathophysiology of chronic wounds: current state and future directions

I Pastar, NC Balukoff, J Marjanovic… - Cold Spring …, 2023 - cshperspectives.cshlp.org
Venous leg ulcers, diabetic foot ulcers, and pressure ulcers are complex chronic wounds
with multifactorial etiologies that are associated with high patient morbidity and mortality …

Macrophages in skin wounds: functions and therapeutic potential

SL Sim, S Kumari, S Kaur, K Khosrotehrani - Biomolecules, 2022 - mdpi.com
Macrophages regulate cutaneous wound healing by immune surveillance, tissue repair and
remodelling. The depletion of dermal macrophages during the early and middle stages of …

Pyroptosis and inflammasomes in diabetic wound healing

X Mu, X Wu, W He, Y Liu, F Wu, X Nie - Frontiers in Endocrinology, 2022 - frontiersin.org
Diabetic wound is one of the complications of diabetes and is not easy to heal. It often
evolves into chronic ulcers, and severe patients will face amputation. Compared with normal …

Relevance of NLRP3 inflammasome‐related pathways in the pathology of diabetic wound healing and possible therapeutic targets

Y Ding, X Ding, H Zhang, S Li… - Oxidative Medicine and …, 2022 - Wiley Online Library
Wound healing is a major secondary complication in type 2 diabetes, which results in
significant disability and mortality, imposing a significant clinical and social burden …

Sub 150 nm nanoscale gallium based metal–organic frameworks armored antibiotics as super penetrating bombs for eradicating persistent bacteria

K Huang, J Wang, Q Zhang, K Yuan… - Advanced Functional …, 2022 - Wiley Online Library
Persistent bacteria, such as intracellular and biofilm bacteria, are critical challenges in clinic
treatment because they are refractory to antibiotics management under the shelter of …

Fig latex inhibits the growth of pathogenic bacteria invading human diabetic wounds and accelerates wound closure in diabetic mice

M Salah, G Badr, HF Hetta, WA Khalifa, AA Shoreit - Scientific Reports, 2022 - nature.com
Impaired wound healing is one of the most critical complications associated with diabetes
mellitus. Infections and foot ulcers are major causes of morbidity for diabetic patients. The …

[HTML][HTML] Cold atmospheric plasma induces the curing mechanism of diabetic wounds by regulating the oxidative stress mediators iNOS and NO, the pyroptotic …

G Badr, FM El-Hossary, FEM Lasheen, NZ Negm… - Biomedicine & …, 2023 - Elsevier
It has been demonstrated that cold atmospheric plasma (CAP) accelerates the wound
healing process, however the underlying molecular pathways behind this effect remain …

The wound microbiome

EK White, EA Grice - Cold Spring Harbor Perspectives in …, 2023 - cshperspectives.cshlp.org
Breach of the skin barrier and subsequent wound healing occur in the context of microbial
communities of bacteria, fungi, and viruses. These polymicrobial communities are dynamic …

[HTML][HTML] Deciphering the emerging role of programmed cell death in diabetic wound healing

J Song, K Zhu, H Wang, M Wu, Y Wu… - International Journal of …, 2023 - ncbi.nlm.nih.gov
Diabetic wounds are characterized by delayed and incomplete healing. As one of the most
common complications of diabetes, diabetic wounds can be fatal in some cases …

Inflammasome activation by Gram-positive bacteria: Mechanisms of activation and regulation

AM Keestra-Gounder, PE Nagao - Frontiers in Immunology, 2023 - frontiersin.org
The inflammasomes are intracellular multimeric protein complexes consisting of an innate
immune sensor, the adapter protein ASC and the inflammatory caspases-1 and/or-11 and …