The presence of ROS is a constant feature in living cells metabolizing O2. ROS
concentration and compartmentation determine their physiological or pathological effects …

Cancer chemoprevention is defined as the use of natural, synthetic, or biologic chemical
agents to reverse, suppress, or prevent carcinogenic progression to invasive cancer. The …

The present study evaluated the preclinical pharmacokinetics and pharmacodynamics of
trans‐pterostilbene, a constituent of some plants. Right jugular vein cannulated male …

CXCL8 (also known as IL‐8) can produce different biological effects by binding to its
receptors: CXCR1, CXCR2, and the Duffy antigen receptor for chemokines (DARC). CXCL8 …

It is well established that chronic inflammation underpins the development of a number of
human cancers, with pro-inflammatory signaling within the tumor microenvironment …

Publisher Summary This chapter focuses on selective inhibitors of cyclooxygenase-2 (COX-
2). Two distinct COX enzymes were recently identified (i) a constitutive form (COX-1) present …

Nonsteroidal anti-inflammatory drugs (NSAIDs) are well-known cancer preventives, which
have been largely attributed to their antiproliferative and apoptosis-inducing activities. In this …

Two enzymes, cyclo-oxygenase (COX) and 5-lipoxygenase, act upon arachidonic acids to
produce prostaglandins and leukotrienes. Inhibition of COX-2 by non-steroidal anti …

HIF1α and NFkB are two transcription factors very frequently activated in tumors and
involved in tumor growth, progression, and resistance to chemotherapy. In fact, HIF1α and …

Aspirin decreases the risk of colorectal cancer, reportedly through suppression of
cyclooxygenase (COX) activity. Using a rat model of colonic adenocarcinoma, we compared …