[HTML][HTML] Using genetic association data to guide drug discovery and development: review of methods and applications
Evidence on the validity of drug targets from randomized trials is reliable but typically
expensive and slow to obtain. In contrast, evidence from conventional observational …
expensive and slow to obtain. In contrast, evidence from conventional observational …
[HTML][HTML] Body fatness associations with cancer: evidence from recent epidemiological studies and future directions
This narrative review highlights current evidence linking greater body fatness to risk of
various cancers, with focus on evidence from recent large cohort studies and pooled …
various cancers, with focus on evidence from recent large cohort studies and pooled …
Causal role of high body mass index in multiple chronic diseases: a systematic review and meta-analysis of Mendelian randomization studies
SC Larsson, S Burgess - BMC medicine, 2021 - Springer
Background Obesity is a worldwide epidemic that has been associated with a plurality of
diseases in observational studies. The aim of this study was to summarize the evidence from …
diseases in observational studies. The aim of this study was to summarize the evidence from …
Association between genetically proxied PCSK9 inhibition and prostate cancer risk: A Mendelian randomisation study
Background Prostate cancer (PrCa) is the second most prevalent malignancy in men
worldwide. Observational studies have linked the use of low-density lipoprotein cholesterol …
worldwide. Observational studies have linked the use of low-density lipoprotein cholesterol …
[HTML][HTML] Cancer and obesity: an obesity medicine association (OMA) clinical practice statement (CPS) 2022
E Lazarus, HE Bays - Obesity Pillars, 2022 - Elsevier
Abstract Background This Obesity Medicine Association (OMA) Clinical Practice Statement
(CPS) provides an overview of cancer and increased body fat. Methods The scientific …
(CPS) provides an overview of cancer and increased body fat. Methods The scientific …
Selenium and cancer risk: Wide‐angled Mendelian randomization analysis
Evidence on the association between selenium and cancer risk is inconclusive. We
conducted a Mendelian randomization study to examine the associations of selenium levels …
conducted a Mendelian randomization study to examine the associations of selenium levels …
Morning chronotype and digestive tract cancers: Mendelian randomization study
Morning chronotype has been associated with a reduced risk of prostate and breast cancer.
However, few studies have examined whether chronotype is associated with digestive tract …
However, few studies have examined whether chronotype is associated with digestive tract …
Associations between an obesity-related dietary pattern and incidence of overall and site-specific cancers: a prospective cohort study
M Maimaitiyiming, H Yang, L Zhou, X Zhang, Q Cai… - BMC medicine, 2023 - Springer
Background A dietary pattern (DP) may impact on cancer incidence more strongly than
individual foods, but this association remains uncertain. Here, we aimed to broadly explore …
individual foods, but this association remains uncertain. Here, we aimed to broadly explore …
The timing of adiposity and changes in the life course on the risk of cancer
Z Fang, EL Giovannucci - Cancer and Metastasis Reviews, 2022 - Springer
Excess body weight has been established as a risk factor for at least twelve cancer sites,
though questions remain as to the timing of associations for adiposity and cancer risk …
though questions remain as to the timing of associations for adiposity and cancer risk …
Global epidemiology of epithelial ovarian cancer
Globally, ovarian cancer is the eighth most common cancer in women, accounting for an
estimated 3.7% of cases and 4.7% of cancer deaths in 2020. Until the early 2000s, age …
estimated 3.7% of cases and 4.7% of cancer deaths in 2020. Until the early 2000s, age …