[HTML][HTML] The analysis of the human megakaryocyte and platelet coding transcriptome in healthy and diseased subjects
K De Wispelaere, K Freson - International Journal of Molecular Sciences, 2022 - mdpi.com
Platelets are generated and released into the bloodstream from their precursor cells,
megakaryocytes that reside in the bone marrow. Though platelets have no nucleus or DNA …
megakaryocytes that reside in the bone marrow. Though platelets have no nucleus or DNA …
Baffled‐flow culture system enables the mass production of megakaryocytes from human embryonic stem cells by enhancing mitochondrial function
X Wu, B Zhang, K Chen, J Zhao, Y Li, J Li… - Cell …, 2023 - Wiley Online Library
Human embryonic stem cells (hESCs) have become an ideal cell source for the ex vivo
generation of megakaryocyte (MK) and platelet products for clinical applications. However …
generation of megakaryocyte (MK) and platelet products for clinical applications. However …
[HTML][HTML] Proinflammatory phenotype of iPS cell-derived JAK2 V617F megakaryocytes induces fibrosis in 3D in vitro bone marrow niche
N Flosdorf, J Böhnke, MAS de Toledo, N Lutterbach… - Stem cell reports, 2024 - cell.com
The myeloproliferative disease polycythemia vera (PV) driven by the JAK2 V617F mutation
can transform into myelofibrosis (post-PV-MF). It remains an open question how JAK2 …
can transform into myelofibrosis (post-PV-MF). It remains an open question how JAK2 …
[HTML][HTML] MAGNETO: Cell type marker panel generator from single-cell transcriptomic data
Single-cell RNA sequencing experiments produce data useful to identify different cell types,
including uncharacterized and rare ones. This enables us to study the specific functional …
including uncharacterized and rare ones. This enables us to study the specific functional …
The impact of the JAK2 V617F mutation on megakaryocytes and bone marrow fibrosis in an iPS cell model
N Flosdorf, R Schneider-Kramann, M Zenke… - 2023 - publications.rwth-aachen.de
Die Erfindung der induzierten pluripotenten Stammzellen (iPS-Zellen) ermöglichte es
Forschern, menschliche Stammzellen, ihre Differenzierung, die Entwicklung von Organen …
Forschern, menschliche Stammzellen, ihre Differenzierung, die Entwicklung von Organen …