Adipocyte, immune cells, and miRNA crosstalk: a novel regulator of metabolic dysfunction and obesity

S Kiran, V Kumar, S Kumar, RL Price, UP Singh - Cells, 2021 - mdpi.com
Obesity is characterized as a complex and multifactorial excess accretion of adipose tissue
(AT) accompanied with alterations in the immune response that affects virtually all age and …

[HTML][HTML] Subcutaneous adipose tissue diseases: Dercum disease, lipedema, familial multiple lipomatosis, and Madelung disease

KL Herbst - Endotext [Internet], 2019 - ncbi.nlm.nih.gov
Subcutaneous adipose tissue diseases involving adipose tissue and its fascia, also known
as adipofascial disorders, represent variations in the spectrum of obesity. The adipofascia …

LncRNAs: potential novel prognostic and diagnostic biomarkers in colorectal cancer

N Dastmalchi, R Safaralizadeh… - Current medicinal …, 2020 - ingentaconnect.com
Background: Long non-coding RNAs (lncRNAs), a type of regulatory RNAs, play a key role
in numerous cellular pathways. Ectopic expression of this group of non-coding RNAs has …

Multi-faceted role of cancer-associated adipocytes in colorectal cancer

A Grigoraș, C Amalinei - Biomedicines, 2023 - mdpi.com
Colorectal cancer (CRC) is one of the most commonly diagnosed types of cancer, especially
in obese patients, and the second cause of cancer-related death worldwide. Based on these …

Obesity: more than an inflammatory, an infectious disease?

PCL Leocádio, RB Oriá, ME Crespo-Lopez… - Frontiers in …, 2020 - frontiersin.org
Much is discussed if obesity or diet components modify the “healthy” microbiota or if
microbiota modifications trigger events that culminate in obesity. This association is probably …

Immune dysfunctions and immunotherapy in colorectal cancer: the role of dendritic cells

S Gessani, F Belardelli - Cancers, 2019 - mdpi.com
Colorectal cancer (CRC), a multi-step malignancy showing increasing incidence in today's
societies, represents an important worldwide health issue. Exogenous factors, such as …

Dietary fatty acids at the crossroad between obesity and colorectal cancer: fine regulators of adipose tissue homeostasis and immune response

M Del Cornò, R Varì, B Scazzocchio, B Varano… - Cells, 2021 - mdpi.com
Colorectal cancer (CRC) is among the major threatening diseases worldwide, being the
third most common cancer, and a leading cause of death, with a global incidence expected …

Type I interferons as joint regulators of tumor growth and obesity

S Gessani, F Belardelli - Cancers, 2021 - mdpi.com
Simple Summary The escalating global epidemic of overweight and obesity is a major public
health and economic problem, as excess body weight represents a significant risk factor for …

SHP2 regulates adipose maintenance and adipocyte-pancreatic cancer cell crosstalk via PDHA1

AA Olou, J Ambrose, JL Jack, MK Walsh… - Journal of Cell …, 2023 - Springer
Adipocytes are the most abundant cell type in the adipose tissue, and their dysfunction is a
significant driver of obesity-related pathologies, such as cancer. The mechanisms that (1) …

Properties of leukemic stem cells in regulating drug resistance in acute and chronic myeloid leukemias

X Zhai, X Jiang - Biomedicines, 2022 - mdpi.com
Notoriously known for their capacity to reconstitute hematological malignancies in vivo,
leukemic stem cells (LSCs) represent key drivers of therapeutic resistance and disease …