Wingless ligands, a family of secreted proteins, are critically involved in organ development
and tissue homeostasis by ensuring balanced rates of stem cell proliferation, cell death and …

MicroRNAs (miRNAs) are small non-coding RNAs, which function as critical
posttranscriptional regulators of gene expression by promoting mRNA degradation and …

Dysregulated extravillous trophoblast invasion and proliferation are known to increase the
risk of recurrent spontaneous abortion (RSA); however, the underlying mechanism remains …

Implantation involves an extensive cross talk between the trophoblast cells and the receptive
endometrium through embryonic as well as endometrial‐derived factors that regulate the …

The placenta is the main determinant of fetal growth and development in utero. It supplies all
the nutrients and oxygen required for fetal growth and secretes hormones that facilitate …

In humans, cell fusion is restricted to only a few cell types under normal conditions. In the
placenta, cell fusion is a critical process for generating syncytiotrophoblast: the giant …

Many proliferative, invasive, and immune tolerance mechanisms that support normal human
pregnancy are also exploited by malignancies to establish a nutrient supply and evade or …

Malaria remains a global health burden with Plasmodium falciparum accounting for the
highest mortality and morbidity. Malaria in pregnancy can lead to the development of …

The success of pregnancy is a result of countless ongoing interactions between the placenta
and the maternal immune and cardiovascular systems. Pre‐eclampsia is a serious …

In the first trimester the extravillous cytotrophoblast cells occlude the uterine spiral arterioles
creating a low oxygen environment early in pregnancy, which is essential for pregnancy …