Mutational processes that alter large genomic regions occur frequently in developing
tumors. They range from simple copy number gains and losses to the shattering and …

Aneuploidy has been recognized as a hallmark of tumorigenesis for more than 100 years,
but the connection between chromosomal errors and malignant growth has remained …

Most cancers exhibit aneuploidy, but its functional significance in tumor development is
controversial. Here, we describe ReDACT (Restoring Disomy in Aneuploid cells using …

Mitotic errors lead to aneuploidy, a condition of karyotype imbalance, frequently found in
cancer cells. Alterations in chromosome copy number induce a wide variety of cellular …

Aneuploidy, a genomic alternation characterized by deviations in the copy number of
chromosomes, affects organisms from early development through to aging. Although it is a …

Clinical decisions in cancer rely on precisely assessing patient risk. To improve our ability to
identify the most aggressive malignancies, we constructed genome-wide survival models …

Aneuploidy is a hallmark of human cancers, but the effects of aneuploidy on protein
expression remain poorly understood. To uncover how chromosome copy number changes …

Chromosome instability (CIN) is the most common form of genome instability and is a
hallmark of cancer. CIN invariably leads to aneuploidy, a state of karyotype imbalance. Here …

Many cancers harbor pro-proliferative mutations of the mitogen-activated protein kinase
(MAPK) pathway. In BRAF-driven melanoma cells treated with BRAF inhibitors …

High levels of aneuploidy and chromosomal instability (CIN) are correlated with poor patient
outcomes, though the mechanism (s) underlying this relationship have not been established …